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Clinical Trials/NCT01775267
NCT01775267
Terminated
Phase 2

ASSOCIATING LIVER PARTITION WITH PORTAL VEIN LIGATION FOR STAGED HEPATECTOMY (ALPPS) Versus Conventional Portal Vein Occlusion (PVO) for Resection of Liver Tumors Unresectable in One Step - a Randomized Controlled Trial

University of Zurich3 sites in 3 countries7 target enrollmentNovember 2012
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ConditionsLiver Tumors Not Resectable in One Surgical Procedure

Overview

Phase
Phase 2
Intervention
Not specified
Conditions
Liver Tumors Not Resectable in One Surgical Procedure
Sponsor
University of Zurich
Enrollment
7
Locations
3
Primary Endpoint
Liver free of tumors [ Time Frame: At 3 months ] [ Designated as safety issue: No ]
Status
Terminated
Last Updated
10 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

This randomized phase II trial compares how well associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) or portal vein occlusion (PVO) works in treating patients with liver cancer. Both treatments are types of 2-stage hepatectomies for removing liver cancer. ALPPS may be more effective than PVO in patients whose disease would traditionally be considered inoperable.

  • Trial with surgical intervention
Registry
clinicaltrials.gov
Start Date
November 2012
End Date
November 2015
Last Updated
10 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Liver free of tumors [ Time Frame: At 3 months ] [ Designated as safety issue: No ]

Time Frame: 2012 to 2015

Secondary Outcomes

  • rate of hypertrophy over time(2012 to 2015)
  • Complications of treatment(2012-2015)
  • Postoperative liver and renal function(2012 to 2015)
  • Progression of disease(2012-2015)

Study Sites (3)

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