ALLPS VERSUS PVO Randomized Controlled Trial
- Conditions
- Liver Tumors Not Resectable in One Surgical Procedure
- Registration Number
- NCT01775267
- Lead Sponsor
- University of Zurich
- Brief Summary
This randomized phase II trial compares how well associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) or portal vein occlusion (PVO) works in treating patients with liver cancer. Both treatments are types of 2-stage hepatectomies for removing liver cancer. ALPPS may be more effective than PVO in patients whose disease would traditionally be considered inoperable.
* Trial with surgical intervention
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 7
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Liver free of tumors [ Time Frame: At 3 months ] [ Designated as safety issue: No ] 2012 to 2015
- Secondary Outcome Measures
Name Time Method rate of hypertrophy over time 2012 to 2015 Complications of treatment 2012-2015 Postoperative liver and renal function 2012 to 2015 Progression of disease 2012-2015 Progression free survival
Trial Locations
- Locations (3)
Washington University
🇺🇸St. Louis, Missouri, United States
Italian Hospital, Department of Surgery, Division of HPB surgery and Liver Transplatn Unit
🇦🇷Buenos Aires, Argentina
University Hospital Zurich, Division of Visceral and Transplant Surgery
🇨🇭Zurich, ZH, Switzerland
Washington University🇺🇸St. Louis, Missouri, United States