Diagnosis of Bladder Pain Syndrome / Interstitial Cystitis
Not Applicable
Completed
- Conditions
- Interstitial CystitisOveractive BladderBladder Pain Syndrome
- Interventions
- Procedure: biopsy
- Registration Number
- NCT03023241
- Lead Sponsor
- Cantonal Hospital, Frauenfeld
- Brief Summary
To identify new, simple and reliable biomarkers for bladder pain syndrome/interstitial cystitis (BPS/IC) for diagnosis of this disease.
- Detailed Description
Collection and analyses of bladder biopsies, bladder washings, blood and urine samples of patients with bladder pain syndrome/interstitial cystitis (BPS/IC), overactive bladder syndrome (OAB) and bladder-healthy controls. Analyses include ELISA, RT-qPCR, DNA sequencing, and immunohistochemistry techniques. Differences between patient groups are statistically evaluated.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 300
Inclusion Criteria
- patient with diagnosed BPS/IC, OAB or healthy controls
- included healthy controls must have another pelvic surgery planned (e.g. hysterectomy)
- being able to act and judge
Exclusion Criteria
- unstable endocrinological situation
- severe illness
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description all study patients biopsy Same intervention for all subjects: anamnesis, questionnaires and biological samples (bladder biopsy, bladder washing, blood and urine) are collected at one single visit.
- Primary Outcome Measures
Name Time Method Identification of new diagnostic markers for BPS/IC 2 days
- Secondary Outcome Measures
Name Time Method Identification of molecular details that lead to BPS/IC (pathogenesis). 2 days
Trial Locations
- Locations (1)
Cantonal Hospital Frauenfeld
🇨🇭Frauenfeld, Thurgau, Switzerland