Effect of Intradialytic Administration of Ketoacid Analogues on Inflammatory Parameters in Patients Undergoing Chronic Hemodialysis Twice a Week
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- interleukin-6
研究概览
简要总结
this study tries to measure the effect of intradialytic ketoacid analogues on inflammatory parameters
详细描述
this study will measure inflammation parameters:
- interleukin 6
- malnutrition inflammation score
- neutrophil lymphocyte ratio
- monocyte lymphocyte ratio
- thrombocyte lymphocyte ratio
the duration of intervention is 12 weeks
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient who undergo hemodialysis two times a week
排除标准
- •travelling hemodialysis
- •acute conditions
- •HIV patient
- •acute infection
- •stroke and immobilized patient
研究组 & 干预措施
intervention
will be given parenteral ketoacid analogues intradialytics two times a week
干预措施: Ketoacid (Drug)
结局指标
主要结局
interleukin-6
时间窗: 12 weeks
in pg/mL, no limit values
malnutrition inflammation score
时间窗: 12 weeks
consists of ten components, based on subjective complaints combined with albumin serum (in g/dL), serum iron (in micromol/L, and total iron binding capacity (in micromol/L). the sum of all components \>5 means have high inflammation status
monocyte lymphocyte ratio
时间窗: 12 weeks
the percentage ratio of monocyte count and lymphocyte count will be combined to monocyte lymphocyte ratio
neutrophil lymphocyte ratio
时间窗: 12 weeks
the percentage ratio of neutrophil count and lymphocyte count will be combined to neutrophil lymphocyte ratio
thrombocyte lymphocyte ratio
时间窗: 12 weeks
the percentage ratio of thrombocyte (in per microliter of blood) and lymphocyte count will be combined to thrombocyte lymphocyte ratio
次要结局
未报告次要终点
研究者
Anggraini Permata Sari
Internal Medicine Staff, Fellow of Nephrology Division
RSUP Fatmawati