Transdiagnostic Mechanisms in Fearful Avoidance

Conditions: anxiety
10002861
depression

Registration Number: NL-OMON52219

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 207

Inclusion Criteria

• Above 18 years of age
• Fluent in Dutch
• Eligible for MRI
• Normal or corrected-to-normal vision
• Normal uncorrected hearing
• Willingness and ability to give written informed consent and willingness and
ability to understand the nature and content, to participate and comply with
the study requirements
For patients:
• Current or recent (i.e. last year) Axis I diagnosis of anxiety (Generalized
Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia), PTSD
or OCD and/or depression) Major Depressive Disorder, Persistent Depressive
Disorder) diagnosis (assessed using the Mini-international Neuropsychiatric
Interview)

Exclusion Criteria

• Insufficient comprehension of the Dutch language
• Abnormal hearing or (uncorrected) vision
• Drug or alcohol addiction in the past 6 months
• Diagnosis of bipolar disorder, schizophrenia, schizophreniform disorder,
schizoaffective illness
• Current psychosis
• Current neurological disorder, past neurological disorder within the last
three months
• Physical, cognitive, or intellectual impairments interfering with
participation, such as deafness, blindness, or sensorimotor handicaps
• History of cardiac disease

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• Functional Magnetic Resonance Imaging (fMRI)<br /><br>• Psychophysiological recordings (heart rate, electromyography)<br /><br>• Behavioural measures of avoidance behaviour (choice: approach/avoid)<br /><br>• Self-report questionnaires (treatment outcome, avoidance questionnaire) </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Resting state fMRI<br /><br>• Electrodermal activity<br /><br>• Breathing rate<br /><br>• Questionnaires (anxiety symptoms, depressive symptoms, cognitive avoidance,<br /><br>intolerance of uncertainty, motivational systems)</p><br>