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临床试验/NCT03103230
NCT03103230已完成不适用

Recherche de Marqueurs Pronostiques électro-physiologiques précoces Chez l'Aphasique après un Accident Vasculaire cérébral.APHA-TMS

University Hospital, Bordeaux2 个研究点 分布在 1 个国家目标入组 130 人开始时间: 2014年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
130
试验地点
2
主要终点
Evolution of aphasia

研究概览

简要总结

The purpose of this study is to study, among the aphasic person, if motor function ( studied by Motor Evoked Potentials) performed within the first 14 days after a stroke can predict a good recovery from aphasia 6 months of the initial episode.

详细描述

• Background : Stroke affects approximately 130,000 people per year and communication disorders occur in 35% of cases, resulting in left brain damages. Aphasia is the main cause of these disorders. It is a sign of poor prognosis in the functional recovery after stroke. Recent studies have attempted to establish early clinical prognostic criteria to establish a predictive model of aphasia recovery. The issue of the possibility of prediction is important and can influence the rehabilitation treatment decided in the early days after stroke, with adequate guidance in rehabilitation structures.

There are close links between motor system and language, either at production or comprehension, and more particularly concerning the motricity of the hand or lips. The cortical excitability of motor areas of the right upper limb is thus modified by the language in healthy subjects, but also in the aphasic person.

  • Purpose : The main: to study, among the aphasic person, if Motor Evoked Potentials (MEP) performed within the first 14 days after a stroke can predict a good recovery from aphasia 6 months of the initial episode.
  • Detailed description: All aphasic stroke patients with ischemic or hemorrhagic damages will be proposed for inclusion. All patients will benefit in the acute phase of an aphasia evaluation, and a clinical evaluation. All patients will have a study of motor evoked potentials (abductor pollicis brevis and orbicularis oris) less than 14 days from stroke. The investigators will evaluate the aphasia 3 and 6 months after stroke, to determinate if MEP can predict a good recovery of aphasia.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All patients with a left stroke (first clinical episode deficit) imaging confirmed.
  • With aphasia (-1 language analysis in the acute phase and severity of the questionnaire LAST (Flamand-Roze, Falissard et al. 2011))
  • Right-handed (Edinburgh Handedness Inventory)
  • Free of dementia before stroke
  • Older than 18 years
  • Able to hold a sitting in chair.
  • Included in maximum 14 days after stroke
  • Patient social security system
  • Free Consent, informed writing signed by the participant or the person of confidence and the investigator (no later than the day of inclusion and before any examination required by research)

排除标准

  • Refusal of the consent
  • Impaired alertness
  • Dementia prior to stroke
  • Illiteracy
  • Severe dysarthria
  • Previous psychiatric history requiring hospitalization in a specialized environment for more than two months
  • Major visual or auditory perceptual disorder
  • Previous epilepsy or seizures in hyperacute phase of stroke
  • Treatment strongly interacting with GABAergic or glutamatergic system
  • Contraindication to MEP: clip intracranial ferromagnetic pacemakers, cochlear implant, intracerebral stimulator.

结局指标

主要结局

Evolution of aphasia

时间窗: 6 months after stroke

Aphasia Severity Rating Scale (ASRS)

次要结局

  • Evolution of aphasia(3 months after stroke)
  • Pattern of aphasia(3 & 6 months after stroke)

研究者

发起方
University Hospital, Bordeaux
申办方类型
Other
责任方
Sponsor

研究点 (2)

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