Efficacy of Platelet Rich Fibrin as a Graft and Membrane Versus Hyaluronic Acid and Amniotic Membrane in the Treatment of Mandibular Grade II and Grade III Furcation Defects- A Randomized Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Furcation Defects
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- Radiological Parameters
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This study is intended to compare the efficacy of platelet-rich fibrin as a graft and a membrane versus hyaluronic acid(Gengigel) and amniotic membrane in the treatment of mandibular grade II furcation defects.
Detailed Description
Platelet-rich fibrin is a fraction of plasma that provides a rich source of growth factors and may enhance the stabilization and revascularization of the flaps and grafts. Hyaluronic acid is a naturally occurring non-sulfated high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration and proliferation. Hence its administration to periodontal wound sites could achieve beneficial effects in periodontal tissue regeneration. Amniotic membrane is being used for various regenerative procedures as it is a rich source of various collagen and non-collagen proteins such as laminin, fibronectin and proteoglycan.
Investigators
Boyeena Lavanya
Student
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Eligibility Criteria
Inclusion Criteria
- •Grade II furcation involvement
Exclusion Criteria
- •Pregnant and lactating women,
- •Systemically compromised patients
Outcomes
Primary Outcomes
Radiological Parameters
Time Frame: Baseline and 9 months post surgery.
Amount of Bone fill in the furcation (Change in Bone level) to be measured by Cone Beam Computed Tomography(CBCT)
Secondary Outcomes
- Clinical Parameter(Baseline and 9 months post surgery)