Comparison of Platelet Rich Fibrin as Graft & Membrane Vs Hyaluronic Acid & Amniotic Membrane in the Treatment of Interradicular Defects
- Conditions
- Furcation Defects
- Registration Number
- NCT03578744
- Brief Summary
This study is intended to compare the efficacy of platelet-rich fibrin as a graft and a membrane versus hyaluronic acid(Gengigel) and amniotic membrane in the treatment of mandibular grade II furcation defects.
- Detailed Description
Platelet-rich fibrin is a fraction of plasma that provides a rich source of growth factors and may enhance the stabilization and revascularization of the flaps and grafts.
Hyaluronic acid is a naturally occurring non-sulfated high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration and proliferation. Hence its administration to periodontal wound sites could achieve beneficial effects in periodontal tissue regeneration.
Amniotic membrane is being used for various regenerative procedures as it is a rich source of various collagen and non-collagen proteins such as laminin, fibronectin and proteoglycan.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 14
- Grade II furcation involvement
- Smokers,
- Pregnant and lactating women,
- Systemically compromised patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Radiological Parameters Baseline and 9 months post surgery. Amount of Bone fill in the furcation (Change in Bone level) to be measured by Cone Beam Computed Tomography(CBCT)
- Secondary Outcome Measures
Name Time Method Clinical Parameter Baseline and 9 months post surgery Change in relative horizontal clinical attachment level will be measured in millimeters by the Nabers probe in the furcation area
Trial Locations
- Locations (1)
Dr.Rekha Rani Koduganti
🇮🇳Hyderabad, Telangana, India
Dr.Rekha Rani Koduganti🇮🇳Hyderabad, Telangana, India