Comparison of Platelet Rich Fibrin as Graft & Membrane Vs Hyaluronic Acid & Amniotic Membrane in the Treatment of Interradicular Defects

Not Applicable

Completed

• Conditions: Furcation Defects
• Interventions: Procedure: Conventional Flap surgery

• Registration Number: NCT03578744
• Lead Sponsor: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Brief Summary

This study is intended to compare the efficacy of platelet-rich fibrin as a graft and a membrane versus hyaluronic acid(Gengigel) and amniotic membrane in the treatment of mandibular grade II furcation defects.

Detailed Description

Platelet-rich fibrin is a fraction of plasma that provides a rich source of growth factors and may enhance the stabilization and revascularization of the flaps and grafts.

Hyaluronic acid is a naturally occurring non-sulfated high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration and proliferation. Hence its administration to periodontal wound sites could achieve beneficial effects in periodontal tissue regeneration.

Amniotic membrane is being used for various regenerative procedures as it is a rich source of various collagen and non-collagen proteins such as laminin, fibronectin and proteoglycan.

Study Timeline

• Study Start: 2017-11-16
• Study First Submitted: 2018-05-31
• Study First Submitted QC: 2018-07-04
• Study First Posted: 2018-07-06
• Primary Completion: 2018-08-16
• Study Completion: 2018-10-30
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-05
• Last Update Posted: 2018-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Grade II furcation involvement

Exclusion Criteria

• Smokers,
• Pregnant and lactating women,
• Systemically compromised patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Interventional Comparator	Conventional Flap surgery	Group B patients will be treated with conventional flap surgery. The furcation defects will be debrided and Hyaluronic acid (Gengigel) will be placed as a graft. Amniotic membrane (Tata Memorial Hospital Mumbai) will be placed over the graft and later the flap will be sutured.
Interventional	Conventional Flap surgery	Group A patients will be treated with conventional flap surgery. The furcation defects will be debrided and autologous platelet-rich fibrin will be paced as a graft and membrane. Later the flap will be sutured.

Primary Outcome Measures

Name	Time	Method
Radiological Parameters	Baseline and 9 months post surgery.	Amount of Bone fill in the furcation (Change in Bone level) to be measured by Cone Beam Computed Tomography(CBCT)

Secondary Outcome Measures

Name	Time	Method
Clinical Parameter	Baseline and 9 months post surgery	Change in relative horizontal clinical attachment level will be measured in millimeters by the Nabers probe in the furcation area

Trial Locations

Locations (1)

Dr.Rekha Rani Koduganti; 🇮🇳 Hyderabad, Telangana, India