Different routes and forms of uterotonics for treatment of retained placenta

Not Applicable

Completed

Conditions: Pregnancy and Childbirth
Retained placenta
Retained placenta without haemorrhage

Registration Number: ISRCTN10193593

Lead Sponsor: Al-Hayat National Hospital (Saudi Arabia)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Female

Target Recruitment: 281

Inclusion Criteria

1. Booked or un-booked patients who deliver in the study hospitals or those who are transferred to them after delivering elsewhere
2. Gestational age of 28 weeks or more (updated 11/08/2015: was previously 20 weeks or more)
3. Singleton pregnancies
4. =30 minutes interval after the delivery of the baby provided that our routine active management of the third stage was implemented

Exclusion Criteria

1. Maternal hemodynamic instability requiring immediate intervention (pulse > 100 beats per minute, systolic blood pressure <100 mmHg, diastolic blood pressure reduction more than 20 mmHg)
2. Severe postpartum hemorrhage requiring immediate intervention
3. History of RP or MROP in any previous delivery
4. Vaginal birth after previous cesarean scar
5. Associated medical disorders (e.g., pre-eclampsia, gestational hypertension, pre-gestational and gestational diabetes, cardiac diseases)
6. Placenta previa in the current pregnancy or previous pregnancies
7. Stillborn baby
8. Snapped umbilical cord
9. Known uterine anomalies

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Delivery of the placenta within 30 minutes following drug administration (either spontaneously or following controlled cord traction)<br>2. The need for MROP

Secondary Outcome Measures

Name	Time	Method
1. Post-partum hemorrhage defined as drop in the hemoglobin of 2 g/dl between the pre-randomization level or that taken at least 2 weeks before delivery and the hemoglobin measured 24 hours after delivery<br>2. Need for blood transfusion at any time before discharge from the hospital<br>3. Need for additional uterotonic agents to control post-partum hemorrhage<br>4. Need for uterine curettage