Risk Stratification for Hospital-Acquired Venous Thromboembolism in Medical Patients: a Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,353
- 试验地点
- 3
- 主要终点
- Venous thromboembolism
研究概览
简要总结
Hospital-acquired venous thromboembolism (HA-VTE) is one of the leading preventable causes of in-hospital mortality, but prevention of VTE in hospitalized medical patients remains challenging, as preventive measures such as pharmacological thromboprophylaxis (TPX) need to be tailored to individual thrombotic risk.
The broad objective of this project is to improve VTE prevention strategies in hospitalized medical patients by prospectively examining VTE risk factors (including mobility) and comparing existing risk assessment models.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •Admitted for hospitalization >24 hours on a general internal medicine ward
- •Informed consent as documented by signature
排除标准
- •Need for therapeutic anticoagulation (e.g., atrial fibrillation)
- •Life expectancy <30 days
- •Insufficient proficiency of the German or French language
- •Unwilling to provide informed consent
- •Prior enrolment in the study
结局指标
主要结局
Venous thromboembolism
时间窗: Within 90 days of initial hospital admission
Symptomatic, objectively confirmed fatal and non-fatal hospital-acquired venous thromboembolism, including symptomatic distal and proximal deep vein thrombosis and pulmonary embolism after hospital admission
次要结局
- All-cause mortality(During hospitalization (an average of 7 days) and up to 90 days of initial hospital admission)
- Major bleeding(During hospitalization (an average of 7 days) and up to 90 days of initial hospital admission)
- Clinically relevant non-major bleeding(During hospitalization (an average of 7 days) and up to 90 days of initial hospital admission)
- Venous thromboembolism(During the initial hospitalization, an average of 7 days)
- Patient autonomy in the activities of daily living(At discharge (an average of 7 days after initial hospital admission) and at 90 days after admission)
- Length of hospital stay(within 90 days of initial hospital admission)
- Subsequent hospitalizations(Within 90 days of initial hospital admission)