Oxytocin and Incitement to Use Olfactory Stimuli in Restrictive Anorexia Nervosa

Not Applicable

Completed

• Conditions: Anorexia
• Interventions: Other: No intervention; Other: other workshop; Other: olfactory workshop

• Registration Number: NCT02333500
• Lead Sponsor: Fondation Lenval

Brief Summary

This prospective pilot study will compare adolescents with restrictive anorexia nervosa who participated for 3 months at olfactory workshops, patients who did not, and healthy patients.The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level.

Detailed Description

The restrictive anorexia nervosa (AN) in adolescents is an eating disorder with decreased desire to eat (wanting) following olfactory stimulation. Oxytocin is an hormone involved in the neuromodulation of eating behavior, but also involved in olfactory perception in schizophrenia patients, and in social cognition in patients with autism. Its plasma level was found low in anorexic patients compared to control subjects.

Because of the similarity in disorders of social cognition between these three diseases, we assume that the desire to eat evoked by olfactory perception varies with the plasma oxytocin levels.

With a prospective pilot study we will compare patients with AN who participated for 3 months at olfactory workshops, AN patients who did not, and healthy patients.

The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level.

One application of this study will be the use of ocytocyne nasal spray to increase the eating desire and to allow weight regain

Study Timeline

• Study First Submitted: 2014-12-26
• Study First Submitted QC: 2015-01-06
• Study First Posted: 2015-01-07
• Study Start: 2015-02-11
• Status Verified: 2018-07
• Primary Completion: 2018-12-31
• Study Completion: 2018-12-31
• Last Update Submitted: 2019-02-25
• Last Update Posted: 2019-02-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Medical-Review
• Female or male -Sexe,
• 11 to 18 years
• Anorexia nervosa diagnosed according to the criteria DSM V
• Outpatient care or hospitalization
• Be able to answer the clinicals evaluations questionnaires
• Affiliated to social security
• Consentement of the legal representative and the patient

Exclusion Criteria

• Somatic comorbidity associated with diabetes, celiac disease, brain tumor
• Intolerance odors, predisposed to develop asthma and / or respiratory allergies Pathologie chronic rhino-sinus
• Hyposmiques or anosmic
• Patients not of an inclusion criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	No intervention	Rate of oxytocin of the control group
other workshop	other workshop	Influence of other workshop on the rate of oxytocin
olfactory workshop	olfactory workshop	Influence of sensory therapy on the rate of oxytocin

Primary Outcome Measures

Name	Time	Method
Score "Wanting" to olfactory stimuli	at 3 months

Secondary Outcome Measures

Name	Time	Method
Body mass index	at 3 months
Oxytocin serum level	at 3 months
Scores to clinical scales	at 3 months
Scores to "liking"-"wanting" tests	at 3 months
Scores to hedonicity scale	at 3 months

Trial Locations

Locations (1)

Fondation Lenval Hôpitaux pediatriques CHU de Nice Fondation Lenval; 🇫🇷 Nice, France