Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- response time for avoidance and affordance task
研究概览
简要总结
Based in an embodied approach of cognition, several studies have highlighted a direct link between perception of an object or an emotion and the associated motor responses. This study investigated in patients suffering from bipolar affective disorders whether the perception of emotional words involves an automatic sensorimotor simulation of approach and avoidance behaviors, and whether the perception of an object involves an automatic sensorimotor simulation of object prehension (affordance). We hypothesize that, in this pathology, low level (sensorimotor) cognitive processes are preserved whereas high-level (attentional) are altered. 20 patients suffering from bipolar affective disorders and 20 healthy controls will be recruited. The main objective is the emergence of sensorimotor compatibility effects in approach-avoidance task with emotional stimuli (gain between compatible vs incompatible conditions).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For patients:
- •Affiliated or entitled to a social security
- •Aged between 18 and 55
- •Patients of both sexes suffering from bipolar disorders (DSM V criteria) whatever the subtype
- •Stabilized from a point of view clinical and therapeutic
- •Euthymic (score <7 at the Hamilton scale, and score <8 at Young's scale)
- •Must have given their informed consent before their participation in the study
- •Be right-handed (score> 14 on the laterality scale)
- •For control group:
- •Affiliated or entitled to a social security
- •Must have given their informed consent before their participation in the study
- •Be right-handed (score> 14 on the lateral scale)
- •Aged 18 to 55 matched by age (± 5 years), sex, and on the study level of patients (years of schooling after primary school ± 2 years)
排除标准
- •For patients:
- •Thymic acute decompensation
- •Hamilton scale > 8, Young's scale > 9
- •Montreal Cognitive Assessment (MOCA) <26
- •History neurological pathology with cerebral impairment or serious somatic disease
- •Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal) within 6 months.
- •History of head trauma
- •For control group:
- •History of head trauma
- •Neurological pathology with cerebral impairment or serious somatic disease
- •Psychotropic treatment
- •Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal)
研究组 & 干预措施
patients
Patients suffering bipolar affective disorders and who will perform cognitive tasks + IQ + MINI + experimental task
干预措施: cognitive tasks + IQ + MINI (Behavioral)
control group
Healthy volunteers (Control group) who will perform cognitive tasks + experimental task
干预措施: cognitive tasks (Behavioral)
结局指标
主要结局
response time for avoidance and affordance task
时间窗: Months 24
Comparison of response time for avoidance and affordance task between patients and healthy volunteers.
次要结局
- response time and cognitive tests(Months 24)
- response time for affordance task(Months 24)
- correlations with age at onset of the disease, the number of thymic decompensations and the existence of psychotic symptoms(Months 24)