Molecular Transducers of Physical Activity Consortium
- Conditions
- Physical Activity
- Registration Number
- NCT03960827
- Lead Sponsor
- Wake Forest University Health Sciences
- Brief Summary
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, a mechanistic randomized controlled trial (RCT) is conducted, in which adult study participants are randomized to endurance exercise (EE) training, resistance exercise (RE) training, or no exercise Control for a period of approximately 12 weeks. The overarching hypothesis is that there are discoverable molecular transducers that communicate and coordinate the effects of exercise on cells, tissues, and organs, which may initiate processes ultimately leading to the health benefits of exercise. Because this is a mechanistic trial, the main goal is not a single health-related outcome. Rather, the goal is to generate a resource leading to the generation of a map of the molecular responses to exercise that will be used by the Consortium and by the scientific community at large to generate hypotheses for future investigations of the health benefits of PA.
- Detailed Description
Study assessments are completed before and after the intervention period (exercise or control), and at specific interim time points during the intervention. Assessments include measurements of cardiorespiratory fitness, muscular strength, and body composition (including total body bone mineral content) determined by dual-energy x-ray absorptiometry (DXA). There is also collection of blood, muscle, and adipose tissue biospecimens, monitoring of free-living PA level using wearable devices, and completion of participant reported outcomes and health status by interview and/or questionnaire. An additional group of highly active (HA) individuals currently active in either EE (HAEE) or RE (HARE) are recruited for a single acute exercise testing session of either endurance or resistance exercise and other study assessments. MoTrPAC participants are recruited, trained, and assessed via six adult Clinical Centers (CC), involving 10 clinical sites. As part of the MoTrPAC functions, participant data and biological samples are transferred from the clinical sites to the Consortium Coordinating Center (CCC) Data Management, Analysis and Quality Control Center (DMAQC)and to the Biological Sample Repository, and later analyzed by the Consortium Chemical Analysis Sites (CAS) and the Bioinformatics Center (BIC).
Biological samples collected in this project undergo molecular phenotyping, including metabolomic, lipidomic, proteomic, epigenomic, transcriptomic, and genomic analyses. These assays are done at the MoTrPAC CAS.
Overall coordination of the study and analyses occurs at 4 institutions which make up the CCC and the BIC.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1837
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Cardiopulmonary Exercise Test (CPET) VO2 Peak Baseline; Week 12 Changes in CPET VO2 Peak calculated as L/min
Isometric Knee Peak Torque by Group Baseline; Week 12 Changes in peak torque measured in Newton Meters
- Secondary Outcome Measures
Name Time Method HbA1C Baseline; Week 12 Changes in HDL-C (mg/dL)
LDL-C Baseline; Week 12 Changes in LDL-C (mg/dL)
Triglycerides Baseline; Week 12 Changes in Triglycerides (mg/dL)
HDL-C Baseline; Week 12 Changes in HDL-C (mg/dL)
Trial Locations
- Locations (11)
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
University of Colorado Denver
🇺🇸Denver, Colorado, United States
Florida Hospital / Advent Health
🇺🇸Orlando, Florida, United States
Ball State University
🇺🇸Muncie, Indiana, United States
Pennington Biomedical Research Center
🇺🇸Baton Rouge, Louisiana, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
East Carolina University
🇺🇸Greenville, North Carolina, United States
University of Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
University of Texas Medical Branch - Galveston
🇺🇸Galveston, Texas, United States
Scroll for more (1 remaining)University of Alabama at Birmingham🇺🇸Birmingham, Alabama, United States