DRKS00008582已完成不适用
Individualized analysis of the metabolism in critically ill patients with sepsis - MetaSep
niversitätsklinikum Schleswig-Holstein, Campus Kiel Klinik für Anästhesiologie und Operative Intensivmedizin0 个研究点目标入组 31 人开始时间: 2016年10月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 31
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Presence of sepsis or septic shock* and
- •- onset of sepsis or septic shock = 48 hours
- •- adult female and male patients (age = 18 years)
- •- written informed consent by the patient or her/his legal representative
- •*Definition of sepsis according to Sepsis-3 criteria of the Sepsis Definitions Task Force:
- •Evidence or suspicion of infection (Clinical, Laboratory):
- •- Temperature, white blood cell count, heart rate, biomarker
- •- Microbiology
- •- Antibiotic treatment
- •? SOFA-Score = 2: PaO2/FiO2, platelet count, bilirubin, mean arterial blood pressure (MAP), catecholamines, Glasgow-Coma-Score, creatinine, urine output
- •Septic shock defined as a clinical construct of sepsis with persisting hypotension requiring vasopressors to maintain MAP = 65 mmHg and a serum lactate level >2 mmol/L (18 mg/dL) despite adequate volume resuscitation
排除标准
- •1. Preexisting chronic liver disease Child-Pugh-Class C
- •2. Absolute contraindication to enteral nutrition (e.g., gastrointestinal [GI] perforation, obstruction or no GI tract access for any reason)
- •3. Immunosupression or therapy with corticosteroids above cushing-limit (>7.5 mg prednisiolone equivalent)
- •4. Preexisting acute pancreatitis
- •5. Women during pregnancy or lactating women
- •6. Previous participation in this study
- •7. Limitation of therapy or coded Do-not-resuscitate
- •8. Infaust prognosis due to comorbid condition
研究者
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