跳至主要内容
临床试验/NCT05922150
NCT05922150已完成不适用

Efficiency of Low Level Laser Therapy and Ozone on Sequelae After Extraction of Impacted Mandibular Third Molar

University of Baghdad1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2022年3月9日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
已完成
入组人数
60
试验地点
1
主要终点
pain

研究概览

简要总结

Many factors cause third molars to stay impacted in the jaws, hence the extraction of impacted wisdom teeth occurs often in dental clinics. Pain, trismus, and edema are typical postoperative complications following third molar surgery. Various strategies have been developed to prevent or reduce these postoperative complications, Among these is the use of Low-Level Laser Therapy (LLLT), which demonstrates numerous benefits in lowering pain, trismus, and edema by managing inflammation. The precise biological mechanism of action remains unknown. There seems to be evidence that it may have neuro-pharmacological impacts on the production, metabolism, and release of a number of biological compounds, the other option is use of ozone which has antimicrobial effectiveness (viricidal, bactericidal, and fungicidal). Additional well-known advantages include immunological modulatory and stimulating actions, including anti-inflammatory, biosynthetic, anti-hypoxic, and bioenergetic characteristics. Ozone can interact with blood components in the right amounts to positively impact oxygen metabolism and cell energy while also triggering antioxidant defense mechanisms

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 38 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Patients who had mandibular third molar, totally or partially impacted in the bone (Class II-III and position B, Pell and Gregory's classification), in need of surgical extraction, which were evaluated clinically and by radiological examination.
  • Patients who were in age range between 18-40 years old.
  • Patients who were willing to compliance with study and were available for follow up.
  • Patients should be with good oral hygiene and without any acute illness

排除标准

  • Patients with medical condition that prevent any surgical intervention such as patient with recent myocardial infarction, bleeding disorders, psychiatric problem and patients with pacemaker, uncontrolled systemic disease, immunocompromised patient and patients taking corticosteroid and anti-inflammatory drugs.
  • Patients with history of head and neck radiotherapy.
  • Pregnant or lactation women
  • Active advanced uncontrolled periodontal disease and bad oral hygiene, or patients with local acute infection in relation to third molar especially pericoronitis.
  • Patients who suffer from photodermatoses and photosensitized patients (photoallergies).
  • Hyperthyroidism

研究组 & 干预措施

LLLT and ozone group

Experimental

administered of low level laser therapy and ozone gel after extraction of impacted mandibular third molar

干预措施: low level laser therapy (Radiation)

LLLT and ozone group

Experimental

administered of low level laser therapy and ozone gel after extraction of impacted mandibular third molar

干预措施: ozone gel (Drug)

LLLT group

Experimental

administered of low level laser therapy after extraction of impacted mandibular third molar

干预措施: low level laser therapy (Radiation)

ozone group

Experimental

administered of low ozone gel after extraction of impacted mandibular third molar

干预措施: ozone gel (Drug)

结局指标

主要结局

pain

时间窗: baseline to seventh day

measurement of pain by NRS, between 0 and 10, zero meaning no pain and 10 meaning worst imaginable pain

trismus

时间窗: baseline to seventh day

measurement of maximum mouth opening by using digital Vernia

swelling

时间窗: baseline to seventh day

measurement of swelling by using tape, using 3 lines

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Osama Abdulkathim Ali

postgraduate student

University of Baghdad

研究点 (1)

Loading locations...

相似试验

Effect of LLLT and Ozone to Reduce Complications... | 临床试验