Evaluation of the Role of OCT in the Detection of HIV-associated Neurocognitive Disorder
Not Applicable
Completed
- Conditions
- AIDS-Related Dementia Complex
- Registration Number
- NCT02431091
- Lead Sponsor
- Centre Hospitalier Universitaire Saint Pierre
- Brief Summary
The purpose of this study is to determine the sensitivity and specificity of the use of optical coherence tomography to detect HIV-associated neurocognitive disorder compared to MRI and usual cognitive screening tools.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 55
Inclusion Criteria
- HIV infection
- Antiretroviral treatment
- Undetectable plasmatic HIV viral load (viral load<50 copies/ml) for at least 6 months
- Ability to understand and give approved consent
Exclusion Criteria
- Any present or past ophthalmologic illness that may impair OCT results
- Previous cerebral infection with sequel
- Previous cerebrovascular disease with sequel
- Severe psychiatric illness
- Active alcohol or drug abuse
- Active chronic hepatitis C
- Inability to perform french cognitive assessment
- Inability to perform a MRI
- Inability to perform a lumbar puncture
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Number of patients with abnormal OCT (retinal thickness in µm) in patients with abnormal full neurocognitive evaluation Baseline
- Secondary Outcome Measures
Name Time Method Number of patients with abnormal neuroscreen and/or modified dementia scale in patients with abnoraml full neurocognitve evaluation Baseline Correlation between retinal thickness (in µm) and cerebral atrophy in % of brain parenchymal fraction ( measured by cerebral MRI) Baseline
Trial Locations
- Locations (1)
Hopital St Pierre
🇧🇪Brussels, Belgium
Hopital St Pierre🇧🇪Brussels, Belgium