Resistance exercise and non-alcoholic fatty liver disease

Completed

• Conditions: Topic: Metabolic and Endocrine, Oral and Gastrointestinal; Subtopic: Metabolic and Endocrine (all Subtopics); Disease: Metabolic & Endocrine (not diabetes), Hepatology; Digestive System; Other diseases of liver

• Registration Number: ISRCTN26705810
• Lead Sponsor: ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04-23
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

1. Diagnosed NAFLD or raised liver enzymes
2. Type 2 diabetes (diet or metformin controlled)
3. Body mass index (BMI) between 25 - 35 kg/m^2
4. Aged 18 - 70 years
5. Subjects should not already take part in regular exercise

Exclusion Criteria

1. Subjects with kidney disease or in vivo ferrous metal
2. Subjects that have other pre-existing medical conditions which could prevent them from exercising 3 x per week
3. Subjects with type 2 diabetes on insulin or insulin sensitising treatments
4. Subjects with advanced liver disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A quantitative measure of liver fat will be made using H magnetic resonance spectroscopy. Primary and secondary outcome measures will be made at baseline and after the 8 week exercise intervention/8 week control period.

Secondary Outcome Measures

Name	Time	Method
1. Insulin sensitivity<br>2. Lipid oxidation<br>3. Cytokine production<br>4. Regional adiposity<br>5. Body composition<br><br>Primary and secondary outcome measures will be made at baseline and after the 8 week exercise intervention/8 week control period.