NCT01540578已完成不适用
OBSERVATIONAL: Replication Profiling as a Diagnostic Tool in B-cell Acute Lymphoblastic Leukemia (ALL)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Replication-timing changes as a biomarker for further risk prediction by FISH
研究概览
简要总结
This clinical trial is studying biomarkers as a diagnostic tool in samples from younger patients with B-cell acute lymphoblastic leukemia. Finding specific biomarkers may help improve the treatment of patients with B-cell acute lymphoblastic leukemia
详细描述
STUDY SUBTYPE: Ancillary/Correlative
OBSERVATIONAL STUDY MODEL: Case-only
TIME PERSPECTIVE: Retrospective
BIOSPECIMEN RETENTION: Samples with DNA
BIOSPECIMEN DESCRIPTION: Fresh and frozen bone marrow cells
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Frozen viable cell samples from patients with B-cell acute lymphoblastic (ALL) of any outcome from the Children's Oncology Group (COG) ALL Cell Bank (Part 1)
- •Freshand frozen cell samples from patients with B-cell ALL with known outcomes from the COG ALL Cell Bank (Part 2) meeting 1 of the following criteria:
- •Samples from patients who experienced an early recurrence within 36 months of diagnosis (cases)
- •Samples from patients who remain in prolonged remission (controls)
- •No samples meeting either of the following criteria:
- •Very-high-risk features
- •Philadelphia chromosome positive
- •Hypodiploid
- •MLL (11q23) rearranged
- •Known favorable risk factors
- •Hyperdiploid
- •t(12;21) (ETV6/RUNX1)
排除标准
- 未提供
结局指标
主要结局
Replication-timing changes as a biomarker for further risk prediction by FISH
时间窗: 2 months
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Studying Biomarkers in Samples From Younger Patients With Acute Myeloid LeukemiaChildhood Acute Monoblastic Leukemia (M5a)Childhood Acute Monocytic Leukemia (M5b)Childhood Acute Myeloblastic Leukemia Without Maturation (M1)Childhood Acute Myeloid Leukemia/Other Myeloid MalignanciesChildhood Acute Myelomonocytic Leukemia (M4)NCT01642121Children's Oncology Group20
撤回
不适用
Endometriosis Biomarker Discovery StudyChronic Pelvic PainEndometriosisNCT03272360Myriad Genetic Laboratories, Inc.
已完成
不适用
A New Biomarker for the Non-invasive Diagnosis of Rejection After Heart TransplantationHeart Transplant RejectionNCT03477383Vastra Gotaland Region134
招募中
不适用
Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung CancerAdenocarcinoma of LungNode LungNCT05665504H. Lee Moffitt Cancer Center and Research Institute250
已完成
不适用
Biomarker Monitoring in TP53 Mutation CarriersLi-Fraumeni SyndromeHereditary Cancer SyndromesTP53 Gene Germline Mutation CarrierNCT02289326Scripps Health6