locallyl effect of Cyclosporin and Dexamethasone in oral lichen planus
- Conditions
- oral lichenplanuse.lichen planus
- Registration Number
- IRCT2013100114713N1
- Lead Sponsor
- Babol University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 36
Inclusion criteria
Patients with oral lichen planus diagnosed according to modified WHO criteria ; Painful lesions (VAS = 3-7 )
Exclusion criteria
Patients with systemic disease :hypertension, pulmonary disease ,kidney transparent
, heart disease , chronic liver disease, poor controlled diabetes ;
pregnancy or breast feeding and patients who take sterogene based drugs ; Patients who were under local or systemic agents for lichen planus in last two months ; Patients with history of cancer and use immunomodulating drugs in last two months ; oral lichen planuse concurrence with skin lesion or other mucosal lesion ; Patients who take beta blockers ,diuretics, anticonvulsants, barbiturates and ACE inhibitors ; Patient with complete denture.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method esion size. Timepoint: befor intervation, weekly for 6 weeks. Method of measurement: Thongprasom scoring system.;Pain. Timepoint: befor intervation, weekly for 6 weeks. Method of measurement: visual pain score.
- Secondary Outcome Measures
Name Time Method Candidiasis superimposition. Timepoint: weekly for 6 weeks. Method of measurement: culture.;Telangiectasia. Timepoint: weekly for 6 weeks. Method of measurement: clinical examination.;Atrophy. Timepoint: weekly for 6 weeks. Method of measurement: clinical examination.;Mucosal change. Timepoint: weekly for 6 weeks. Method of measurement: clinical examination.;Taste change. Timepoint: weekly for 6 weeks. Method of measurement: questionnaire form.;Burning sensation. Timepoint: weekly for 6 weeks. Method of measurement: questionnaire form.