Comparison Between the Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- Measurement of urine output
研究概览
简要总结
This work aims to investigate the diuretic effect of Aminophylline in comparison to Furosemide in adult patients undergoing cardiac surgical procedures.
详细描述
Acute Kidney injury (AKI) is a serious and common complication after either adult or pediatric cardiac surgery.
The results of a recent meta-analysis suggested that loop diuretics (furosemide) may reduce postoperative creatinine clearance, whereas aldosterone agonists (spironolactone) increase the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI). Diuretics are not recommended for the prevention of AKI, but loop diuretics may be used for the management of volume overload Aminophylline in cardiac surgery can reduce the frequency of AKI and could be used in the prevention of AKI as a safe and efficient modality in high-risk patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 18-65 years.
- •Both sexes.
- •All adult patients presenting for elective cardiac surgical procedures performed on cardiopulmonary bypass (Coronary artery bypass surgery, Cardiac valve repair and/or replacement, Repair of large septal defects, Repair and/or palliation of congenital heart defects, Transplantation, surgery of thoracic aneurysms.).
- •Body mass index (BMI) ranged between 20 and 40 kg/m2.
排除标准
- •Sensitivity or contraindication to Aminophylline or furosemide
- •Stage-5 chronic kidney disease (CKD) [Glomerular filtration rate (GFR) of less than 15 mL/min].
- •The presence of both factors (GFR less than 60 mL/min and albumin greater than 30 mg per gram of creatinine) along with abnormalities of kidney structure or function for greater than three months signifies chronic kidney disease.
- •Recipients of dialysis before surgery.
- •Recipients of solid-organ transplantation before surgery.
- •Emergency cardiac surgical procedures (e.g. left main coronary artery bypass graft, stuck valves, etc).
- •Patient refusal.
研究组 & 干预措施
Aminophylline group (control group)
Patients will receive Aminophylline.
干预措施: Aminophylline (Drug)
Furosemide group
Patients will receive furosemide.
干预措施: Furosemide (Drug)
结局指标
主要结局
Measurement of urine output
时间窗: Two hours after cardiopulmonary bypass
Urine output will be measured at two hours after cardiopulmonary bypass.
次要结局
- Measurement of urine output at completion of cardiopulmonary bypass(48 hours after cardiopulmonary bypass)
- Urea level(48 hours after cardiopulmonary bypass)
- Creatinine level(48 hours after cardiopulmonary bypass)
- Lactate level(48 hours after cardiopulmonary bypass)
- Estimated Glomerular Filtration Rate (eGFR)(48 hours after cardiopulmonary bypass)
- Measurement of fluid balance(48 hours after cardiopulmonary bypass)
研究者
Ahmed Mohamed Hassan
Assistant Lecturer of Anesthesia, surgical ICU and Pain management, Cairo University, Cairo, Egypt
Cairo University