An Observational Study on the Relationship Between Tear Metabolomics and POD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Postoperative delirium during the 3 adys-follow-up after anesthetic resuscitation
研究概览
简要总结
To explore the correlation between tear metabolomics and POD. The purpose of this study was to compare the results of tear metabolomics between POD and non-POD elderly patients undergoing abdominal surgery, to clarify the correlation between tear metabolomics and POD, and to find tear markers related to POD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 65-90 years old;
- •ASA I-III;
- •patients who plan to undergo elective abdominal surgery under general anesthesia;
- •Volunteer to participate in this study and sign informed consent.
排除标准
- •patients with known mental illness or lack of communication or cognitive impairment before operation;
- •severe vision, hearing, language impairment or other reasons unable to communicate with visitors;
- •severe dysfunction of important organs such as heart, brain, lung, liver, kidney, etc.;
- •long-term use of sedatives, antidepressants or alcoholism;
- •patients with severe postoperative complications and admitted to intensive care unit;
- •patients who refused or failed to complete the cognitive function test.
- •patients who could not cooperate with the study for any other reason
结局指标
主要结局
Postoperative delirium during the 3 adys-follow-up after anesthetic resuscitation
时间窗: From ending of the surgery to 3 days after anesthetic resuscitation
Postoperative delirium was tested with 3D-Confusion Assessment Method or Confusion Assessment Method-intensive care unit (0-4, higher scores means worse). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder.
次要结局
- Postoperative delirium on the first day after operation(9：00-10：00 and 15：00-16：00 on The first day after operation)
- Postoperative delirium on the second day after operation(9：00-10：00 and 15：00-16：00 on The second day after operation)
- Postoperative delirium on the third day after operation(9：00-10：00 and 15：00-16：00 on The third day after operation)
- Postoperative delirium in the postanesthesia care unit(From ending of the surgery to the time when discharge from postanesthesia care unit, an average of 30 minutes.)