Quantification of Cannabinoids and Comparison to Post-Surgical Pain Medication Requirements and Surgical Outcomes

Recruiting

• Conditions: Cannabis Use; Post-Surgical Pain; Cancer; Post-Surgical Complication

• Registration Number: NCT04988490
• Lead Sponsor: University of Colorado, Denver

Brief Summary

To determine how daily cannabis use affects surgical outcomes.

Detailed Description

To determine if patients who are daily cannabis users that are undergoing inpatient abdominal surgery for the treatment of cancer are different from non-cannabis users regarding phytocannabinoid and endocannabinoid levels, pain scores, pain medication requirements, and surgical complications.

Study Timeline

• Study First Submitted: 2021-07-26
• Study First Submitted QC: 2021-07-26
• Study First Posted: 2021-08-03
• Study Start: 2021-10-11
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-21
• Last Update Posted: 2024-08-23
• Primary Completion: 2025-05-18
• Study Completion: 2026-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients > 18 years old
• Undergoing abdominal surgery for the treatment of cancer
• Report no cannabis use in the last year or chronic cannabis use (defined as at least weekly use for 3 months or more)

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Exclusion Criteria

• patients with chronic pain, chronic pain syndrome on opioids
• female patients who are pregnant or lactating
• patients who report use of illicit substances

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative opioid consumption	30 days	Postoperative opioid consumption among daily cannabis using and non-cannabis using patients undergoing abdominal surgery for cancer
Correlation of postoperative complications	30 days	Correlation between 30-day post-operative complications, preoperative, and postoperative phytocannabinoid and endocannabinoid levels
Correlation of postoperative opioid consumption	30 days	Correlation between serum phytocannabinoid and endocannabinoid levels, pain scores, and postoperative opioid consumption

Trial Locations

Locations (1)

University of Colorado Hospital; 🇺🇸 Denver, Colorado, United States