The Mysterious on/Off Itch and Erythema During Whole Body Vibration Exercise
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Itch intensity
Study Overview
Brief Summary
Intense itch on the legs sometimes associated with redness can be adverse effects of whole body vibration (WBV) according to own observations and numerous posts in non-professional online-blogs. To the investigators' knowledge, the appearance of itch and/or a rash during WBV exercise has not yet been described.
The research objectives are:
- To determine the effect of WBV on itch rating and its unpleasantness and on skin changes.
- To determine the effect of WBV on immunoglobulin E (IgE) and serum tryptase
Detailed Description
Objectives Intense itch on the legs sometimes associated with redness can be adverse effects of WBV according to the investigators observations and numerous posts in non-professional online-blogs. To the investigators knowledge, the appearance of itch and/or a rash during WBV exercise has not yet been described.
The objectives of this study are:
- to determine the effect of WBV on itch rating and its unpleasantness and on skin changes.
- to determine the effect of WBV on serum tryptase.
Hypothesis The working hypothesis is that repeated WBV leads to an increase of itching and erythema. Further investigators hypothesize that repeated WBV does not lead to an increase in serum tryptase.
Inclusion and exclusion criteria will be evaluated. Subjects will be instructed to not shave their legs one week before the intervention day and to shave only the left leg from the ankle to the knee on the day prior to the intervention day.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •age 18-35 years
- •Informed Consent as documented by signature (Appendix Informed Consent Form)
Exclusion Criteria
- •itchy skin diseases
- •hay fever
- •chronic venous insufficiency
- •peripheral artery disease
- •musculoskeletal diseases or injuries affecting the legs, hips and pelvis
- •BMI < 17 and > 35 kg/m2
- •pregnancy
Arms & Interventions
Whole body vibration training
Healthy female subjects complete whole body vibration training (10 x 1 min exposure)
Intervention: Whole body vibration training (Other)
Outcomes
Primary Outcomes
Itch intensity
Time Frame: 0 months
0 to 10 numerical rating scale (NRS) (best score: 0 - no itch; worst score: 10)
Secondary Outcomes
- Itch characteristics(0 months)
- Skin surface temperature(0 months)
- Itch unpleasantness(0 months)
- Erlanger atopy score(0 months)
- Erythema intensity(0 months)
- Total immunoglobulin E (IgE) concentration(0 months)
- Tryptase concentration(0 months)