The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Concentration of differentially expressed molecules in PACG patients with zonular laxity
研究概览
简要总结
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
详细描述
This study investigates the pathogenesis of PACG by conducting multi-omics analyses of aqueous humor, blood and anterior lens capsule samples from PACG patients with and without concomitant zonular abnormalities, aiming to elucidate the etiology of zonular abnormalities and uncover novel mechanisms underlying their involvement in the pathogenesis of glaucoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinically diagnosed with primary angle-closure glaucoma (PACG)
- •Aged ≥ 50 years, no gender restriction
- •Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
- •Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
- •Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
排除标准
- •Secondary glaucoma
- •History of previous intraocular surgery
- •Systemic diseases that can cause abnormal ocular zonules
- •Other severe ocular diseases
- •Long-term use of medications affecting connective tissue metabolism
研究组 & 干预措施
Case Group A
PACG patients with zonular laxity
干预措施: No Additional Experimental Intervention (Other)
Case Group B
PACG patients without zonular laxity
干预措施: No Additional Experimental Intervention (Other)
Control Group
cataract patients without a history or signs of glaucoma
干预措施: No Additional Experimental Intervention (Other)
结局指标
主要结局
Concentration of differentially expressed molecules in PACG patients with zonular laxity
时间窗: 2 years
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and healthy control subjects, differentially expressed molecules will be identified and quantified by high-throughput omics sequencing and bioinformatics analysis in PACG patients with zonular laxity, and a potential mechanistic network will be constructed based on these molecular changes.
次要结局
未报告次要终点