Comparative study on efficacy of oral ultramicrosized Griseofulvin and Itraconazole on dermatophytic infection of skin

A total of 240 patients presenting to the Department of Dermatology, Eras Lucknow Medical College and Hospital, Lucknow of clinical diagnosis of Tinea Corporis and Tinea Cruris confirmed by potassium hydroxide (KOH) test will be approached for participation in the study. Patients meeting the inclusion and exclusion criteria and giving written consent for participating in the study shall be recruited. History, complete clinical & micobiological examination with photographic documentation will be done before starting treatment and then at each visit. Patients will be randomly divided into two groups – A and B each containing 120 individuals. In group A – Patients will be given oral Itraconazole 100mg twice daily for 8 weeks. In group B – Patients will be given oral ultramicrosized Griseofulvin 500 mg for 8 weeks. Patients will be followed up at 2, 4, and 8 weeks and at each follow-up visit assessment of clinical response  to treatment and photograph will be taken and therapeutic efficacy will  be graded.

If at any point, any patient withdraws the consent  or does not come for 2 consecutive follow-ups despite telephonic reminders. He/She shall be considered dropped out of the study. If and when required CBC, LFT and KFT will be done if abnormality detected, then patient will be excluded from the study.