Advanced Diffusion Imaging in Renal Cancer Patients: Oncologic Control and Renal Functional Reserve

NYU Langone Health1 个研究点分布在 1 个国家目标入组 90 人2022年12月1日

概览

简要总结

The objective of this study is to apply advanced diffusion imaging in a two-pronged assessment of renal mass patients: (1) characterization of lesion malignancy and subtype, and (2) prediction of renal function stability or decline following partial nephrectomy.

注册库

clinicaltrials.gov

开始日期

2022年12月1日

结束日期

2028年12月1日

最后更新

10个月前

研究类型

Interventional

研究设计

Single Group

性别

All

研究者

发起方

NYU Langone Health

责任方

Sponsor

入排标准

入选标准

•Renal mass patients scheduled for laparoscopic partial nephrectomy.
•eGFR above 30 ml/min/m
•Ages 21 to 85
•Must be willing and able to provide consent.

排除标准

•All metal implants and dental implants that have ferromagnetic properties and are unsafe at 3.0 T.
•Pregnant women are not eligible for participating in this study.
•Acute claustrophobia

研究组 & 干预措施

Renal Mass Patients

Patients will be enrolled for 2 MRI visits. These visits will include an approximately 1 hour research MRI scan and a total of between 3 and 5 hours Tc-99m DTPA scan. In each MRI visit, patients will be scanned for approximately one hour including both standard-of-care clinical sequences and research-based Advanced Diffusion Imaging sequences, on a Prisma 3T MRI scanner. Following the MRI exam or on a day not more than a week after the MRI exam, patients will undergo renal function assessment via Tc-99m DTPA scan and patient's kidneys will be scanned using a gamma camera. Proteinuria will be assessed by standard of care urinalysis of specimens collected at each MRI visit for each patient. Blood test will be performed at each visit to estimate GFR (eGFR) from measurement of serum creatinine.

干预措施: Magnetic Resonance Imaging (MRI) Scan

Renal Mass Patients

Patients will be enrolled for 2 MRI visits. These visits will include an approximately 1 hour research MRI scan and a total of between 3 and 5 hours Tc-99m DTPA scan. In each MRI visit, patients will be scanned for approximately one hour including both standard-of-care clinical sequences and research-based Advanced Diffusion Imaging sequences, on a Prisma 3T MRI scanner. Following the MRI exam or on a day not more than a week after the MRI exam, patients will undergo renal function assessment via Tc-99m DTPA scan and patient's kidneys will be scanned using a gamma camera. Proteinuria will be assessed by standard of care urinalysis of specimens collected at each MRI visit for each patient. Blood test will be performed at each visit to estimate GFR (eGFR) from measurement of serum creatinine.

干预措施: Tc-99m Pentetate