Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients With Sickle Cell Anemia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 986
- Locations
- 3
- Primary Endpoint
- To determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia.
Study Overview
Brief Summary
The purpose of this study is to determine how often people with sickle cell anemia develop pulmonary hypertension a serious disease in which blood pressure in the artery to the lungs is elevated.
Men and women 18 years of age and older with sickle cell anemia may be eligible for this study. Participants will undergo an evaluation at Howard University s Comprehensive Sickle Cell Center in Washington, D.C. or at the National Institutes of Health in Bethesda, Maryland. It will include the following:
- medical history
- physical examination
- blood collection (no more than 50 ml., or about 1/3 cup) to confirm the diagnosis of sickle cell anemia, sickle cell trait or beta-thalassemia (Some blood will be stored for future research testing on sickle cell anemia.)
- echocardiogram (ultrasound test of the heart) to check the pumping action of the heart and the rate at which blood travels through the tricuspid valve.
Following this evaluation, a study nurse will contact participants twice a month for 2 months and then once every 3 months for the next 3 years for a telephone interview. The interview will include questions about general health and recent health-related events, such as hospitalizations or emergency room visits.
Detailed Description
Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisis, acute chest syndrome (ACS), and secondary pulmonary hypertension are common complications of sickle cell anemia. Mortality rates of sickle cell patients with pulmonary hypertension are significantly increased as compared to patients without pulmonary hypertension. Recent studies report up to 40% mortality at 22 months after detection of elevated pulmonary artery pressures in sickle cell patients. Furthermore, pulmonary hypertension is thought to occur in up to 30% of clinic patients with sickle cell anemia.
This study is designed to determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia, and to determine whether genetic polymorphisms in candidate genes contribute to its development or response to treatment.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •INCLUSION CRITERIA FOR SICKLE CELL PATIENTS:
- •Male and females over 18 years of age.
- •Diagnosis of sickle cell disease (electrophoretic documentation of SS, SC, or S-beta thallassemia genotype is required).
Exclusion Criteria
- •FOR SICKLE CELL PATIENTS:
- •Hb A-only phenotype and sickle cell trait.
- •Decisionally impaired subjects.
- •Pregnant or lactating women
- •INCLUSION CRITERIA FOR CONTROL SUBJECTS:
- •Male and females African American subjects over 18 years of age.
- •Exclusion of sickle cell disease (electrophoretic documentation of hemoglobin A is required).
- •EXCLUSION CRITERIA FOR CONTROL SUBJECTS:
- •Diagnosis of sickle cell disease (electrophoretic documentation of SS, or SC, or SB thallassemia genotype is required.)
- •Decisionally impaired subjects.
- •Pregnant or lactating women
Arms & Interventions
non-SCD
200 Men and Women without a diagnosis of sickle cell disease 18 years of age or older
SCD
1000 Men and Women with a diagnosis of sickle cell disease
Outcomes
Primary Outcomes
To determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia.
Time Frame: 10 years
predictive of any clinical outcome or response in sickle cell disease will provide preliminary evidence for further investigation
Secondary Outcomes
- To determine whether genetic polymorphisms in candidate genes contribute to its development or response to treatment.(1 year)