Computerized Intervention for Distress Intolerance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- Change in Distress Intolerance Index (DII) score from Baseline through 4-Month Follow-Up
研究概览
简要总结
This study evaluates the impact of a computerized distress intolerance intervention relative to a control intervention on cannabis use-related behavior and neurophysiology.
详细描述
Distress intolerant cannabis users were randomized to a computerized distress intolerance intervention or a control intervention. Primary and secondary outcomes consist of the treatment target, cannabis use-related behavior, and theoretically-relevant neurophysiological processes (i.e., cannabis cue reactivity, response inhibition).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Participants were blind to whether they were in the experimental (Distress Intolerance Intervention) or control (Healthy Behaviors Intervention) condition. All outcome measures were self-report except for the four-month follow-up Cannabis Use Diagnostic interview which was conducted by an interviewer blind to the participant's treatment condition.
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Distress Intolerance Index score >= 20
- •Average cannabis use frequency in the past year >= 2-3/week
排除标准
- •Current suicidal ideation
- •History of psychotic symptoms
- •Bipolar-spectrum disorder without stabilization on medication for >= 3 months
- •Change in psychotropic medication in the past month
- •Current CBT for internalizing or substance use disorders
研究组 & 干预措施
Computerized Distress Intolerance Intervention
Two, 1-hour computerized sessions that include psychoeducation about emotional avoidance, idiographic emotional exposure, and construction of idiographic implementation intentions to practice distress tolerance skills outside of session.
干预措施: Computerized Distress Intolerance Intervention (Behavioral)
Computerized Healthy Behaviors Intervention
Two, 1-hour computerized sessions that focus on psychoeducation about the importance of a healthy lifestyle.
干预措施: Computerized Healthy Behaviors Intervention (Behavioral)
结局指标
主要结局
Change in Distress Intolerance Index (DII) score from Baseline through 4-Month Follow-Up
时间窗: Baseline, post-treatment (i.e., ~1 week following the last treatment session), 1-month follow-up, 4-month follow-up
Self-report measure of Distress Intolerance (Distress Intolerance Index \[DII\]; McHugh \& Otto, 2012). The DII is a self-report measure comprised of 10 items that are summed together to form a total score (minimum: 0; maximum: 40). Higher scores indicate greater distress intolerance (i.e., worse outcome).
Change in Cannabis Use Disorder (CUD) diagnostic criteria from Baseline to 4-Month Follow-Up
时间窗: Baseline, 4-month follow-up
Interviewer-assessed Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 Cannabis Use Disorder diagnostic criteria. DSM-5 Cannabis Use Disorder criteria were assessed via interview at baseline and again at the 4-month follow-up. Total number of Cannabis Use Disorder criteria was used to assess Cannabis Use Disorder severity (minimum score: 0; maximum score: 11). Higher scores indicate greater Cannabis Use Disorder severity (i.e., worse outcome).
Change in Timeline follow-back (TLFB) cannabis use frequency from Baseline through 4-Month Follow-Up
时间窗: Baseline, post-treatment (i.e., ~1 week following the last treatment session), 1-month follow-up, 4-month follow-up
Percent cannabis use days in the past month (Timeline follow-back \[TLFB\]; Hjorthoj et al., 2012). The Timeline follow-back (TLFB) is a self-report measure that assesses cannabis use over the past 4 weeks. Percentage of days on which cannabis was used in the past four weeks was used to assess cannabis use frequency (minimum: 0%; maximum: 100%). Higher scores indicate greater cannabis use frequency (i.e., worse outcome).
Change in Mirror-Tracing Persistence Task (MTPT) quit latency from Baseline to Post-Treatment
时间窗: Baseline, post-treatment (i.e., ~1 week following the last treatment session)
Behavioral measure of Distress Intolerance (Mirror-Tracing Persistence Task \[MTPT\]; Macatee \& Cougle, 2015). The MTPT is a behavioral persistence measure that assesses behavioral distress intolerance via the latency to quit a distressing task. Scores range from 0 seconds to a maximum persistence time of 7 minutes. Lower scores indicate greater distress intolerance (i.e., worse outcome).
Change in Marijuana Problems Scale (MPS) score from Baseline through 4-Month Follow-Up
时间窗: Baseline, post-treatment (i.e., ~1 week following the last treatment session), 1-month follow-up, 4-month follow-up
Self-report measure of marijuana use-related problems (Marijuana Problems Scale \[MPS\]; Stephens et al., 2000). The MPS is a self-report measure of marijuana use-related problem severity in the past month. The measure is comprised of 19 items with a minimum score of 0 and a maximum score of 38. Higher scores indicate greater marijuana use-related problem severity in the past month (i.e., worse outcome).
Change in Marijuana Motives Measure (MMM) score from Baseline through 4-Month Follow-Up
时间窗: Baseline, post-treatment (i.e., ~1 week following the last treatment session), 1-month follow-up, 4-month follow-up
Self-reported motives for cannabis use (Marijuana Motives Measure \[MMM\]; Zvolensky et al., 2007). The Marijuana Motives Measure (MMM) is a self-report measure that assesses different motives for marijuana use. The coping motives subscale was the subscale of interest in this project. The Coping motives subscale is comprised of 4 items that are then averaged (minimum score: 1; maximum score: 5). Greater scores indicate greater coping motives for marijuana use (i.e., worse outcome).
Change in Marijuana Craving Questionnaire (MCQ) score from Baseline to Post-Treatment
时间窗: Baseline, post-treatment (i.e., ~1 week following the last treatment session)
Self-reported state craving for marijuana (Marijuana Craving Questionnaire \[MCQ\]; Heishman et al., 2009). The Marijuana Craving Questionnaire (MCQ) is a self-report measure of current craving for marijuana use. The emotionality subscale was the subscale of interest in this project. The Emotionality subscale is comprised of 5 items that are then averaged (minimum score: 1; maximum score: 7). Greater scores indicate greater marijuana craving (i.e., worse outcome). In this project, the outcome of interest is the extent to which a laboratory stress induction increases state marijuana craving.
次要结局
- Change in electroencephalography (EEG) index of acute stress modulation of response inhibition (assessed by the N200 [N2]) from Baseline to Post-Treatment(Baseline, post-treatment (i.e., ~1 week following the last treatment session))
- Change in electroencephalography (EEG) index of acute stress modulation of cannabis cue reactivity (assessed by the Late Positive Potential [LPP]) from Baseline to Post-Treatment(Baseline, post-treatment (i.e., ~1 week following the last treatment session))
- Change in electroencephalography (EEG) index of acute stress modulation of threat reactivity (assessed by the Late Positive Potential [LPP]) from Baseline to Post-Treatment(Baseline, post-treatment (i.e., ~1 week following the last treatment session))
研究者
Richard Macatee
Assistant Professor
Auburn University