Comparison of Multiple Oxygenation Targets With Different Oximeters in Chronic Obstructive Pulmonary Disease (COPD) and Non-COPD Patients- Impact on Oxygen Flows
- Conditions
- PneumoniaRespiratory DiseaseCOPD ExacerbationHypoxemia
- Interventions
- Device: Masimo oximeterDevice: Nellcor oximeterDevice: Nonin oximeter
- Registration Number
- NCT05819164
- Lead Sponsor
- Laval University
- Brief Summary
The oximeter is an instrument for monitoring patients receiving oxygen therapy. It displays pulse oxygen saturation (SpO2), which is a reflection of arterial oxygen saturation (SaO2). An accurate SpO2 value is essential for optimal management of the O2 flow delivered to patients. Several factors can influence this measurement and the choice of ventilatory support: the type of oximeter used, skin pigmentation and the oxygenation goal.
The objective of our study is to evaluate the impact of the oxygenation goal and the oximeter used on oxygen flows in patients with COPD (or with hypercapnia, or at risk of hypercapnia) and in patients without COPD (in particular pneumonia, pulmonary fibrosis and other pathologies) Our hypothesis is that the SpO2 target and oximeter used will have an impact on oxygen flows and that these effects will be synergistic in these different populations.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 40
- ≥ 18 years old
- On conventional oxygen therapy with SpO2 between 88 and 100% with the usual oximeter and nasal cannula.
- SpO2 < 92% in ambient air with the usual oximeter
- No availability of the SpO2 signal with the usual oximeter
- False nails or nail polish
- Severe anemia documented on the last blood count during the current hospitalization (Hb < 80g/L)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 88% SpO2 target Nonin oximeter During this periods , oxygen will be administered in manual titration to reach 88% of SpO2. 92% SpO2 target Nonin oximeter During this periods , oxygen will be administered in manual titration to reach 92% of SpO2. 92% SpO2 target Masimo oximeter During this periods , oxygen will be administered in manual titration to reach 92% of SpO2. 92% SpO2 target Nellcor oximeter During this periods , oxygen will be administered in manual titration to reach 92% of SpO2. 88% SpO2 target Masimo oximeter During this periods , oxygen will be administered in manual titration to reach 88% of SpO2. 88% SpO2 target Nellcor oximeter During this periods , oxygen will be administered in manual titration to reach 88% of SpO2. 94% SpO2 target Nellcor oximeter During this periods , oxygen will be administered in manual titration to reach 94% of SpO2. 94% SpO2 target Nonin oximeter During this periods , oxygen will be administered in manual titration to reach 94% of SpO2. 96% SpO2 target Masimo oximeter During this periods , oxygen will be administered in manual titration to reach 96% of SpO2. 96% SpO2 target Nonin oximeter During this periods , oxygen will be administered in manual titration to reach 96% of SpO2. 90% SpO2 target Masimo oximeter During this periods , oxygen will be administered in manual titration to reach 90% of SpO2. 90% SpO2 target Nonin oximeter During this periods , oxygen will be administered in manual titration to reach 90% of SpO2. 90% SpO2 target Nellcor oximeter During this periods , oxygen will be administered in manual titration to reach 90% of SpO2. 94% SpO2 target Masimo oximeter During this periods , oxygen will be administered in manual titration to reach 94% of SpO2. 96% SpO2 target Nellcor oximeter During this periods , oxygen will be administered in manual titration to reach 96% of SpO2.
- Primary Outcome Measures
Name Time Method Oxygen flow assessed up to 10 minutes the mean oxygen flow to reach the SpO2 target +/- 1% during 2 minutes for each period and each oximeter
- Secondary Outcome Measures
Name Time Method High oxygen flow assessed up to 10 minutes - until SpO2 target stability for 2 minutes Rate of high oxygen flow (Oxygen flow \>5.0 L/min) to reach the SpO2 target for each period and each oximeter
Oximeter bias comparison assessed up to 10 minutes - until SpO2 target stability for 2 minutes the mean bias between the result of the different oximeter
Partial oxygen weaning assessed up to 10 minutes - until SpO2 target stability for 2 minutes Rate of partial oxygen weaning (Oxygen flow \<=0.5 L/min) to reach the SpO2 target for each period and each oximeter
Complete oxygen weaning assessed up to 10 minutes - until SpO2 target stability for 2 minutes Rate of complete oxygen weaning (Oxygen flow \<=0.1 L/min) to reach the SpO2 target for each period and each oximeter