ISIS 3521 in Treating Patients With Advanced, Unresectable, or Metastatic Non-small Cell Lung Cancer or Unresectable or Metastatic Melanoma
- Conditions
- Lung CancerMelanoma (Skin)
- Registration Number
- NCT00003989
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of ISIS 3521 in treating patients who have advanced, unresectable, or metastatic non-small cell lung cancer or unresectable or metastatic melanoma.
- Detailed Description
OBJECTIVES: I. Determine the complete and partial response rates and duration of response in patients with locally advanced, unresectable, or metastatic non-small cell lung cancer or unresectable or metastatic melanoma treated with ISIS 3521. II. Determine safety of ISIS 3521 in these patients.
OUTLINE: This is a multicenter study. Patients are stratified by disease type. Patients receive ISIS 3521 IV over 21 days followed by 7 days of rest. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 28-50 patients (14-25 per stratum) will be accrued for this study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (27)
Universitaetsklinik
🇦🇹Innsbruck, Austria
Kaiser Franz Josef Hospital
🇦🇹Vienna (Wien), Austria
Institut Jules Bordet
🇧🇪Brussels (Bruxelles), Belgium
Ludwig Institute for Cancer Research-Brussels Branch
🇧🇪Brussels (Bruxelles), Belgium
Universitair Ziekenhuis Antwerpen
🇧🇪Edegem, Belgium
U.Z. Gasthuisberg
🇧🇪Leuven, Belgium
Herlev Hospital - University Hospital of Copenhagen
🇩🇰Herlev, Denmark
Centre Jean Perrin
🇫🇷Clermont-Ferrand, France
Centre Leon Berard
🇫🇷Lyon, France
CRLCC Nantes - Atlantique
🇫🇷Nantes-Saint Herblain, France
Scroll for more (17 remaining)Universitaetsklinik🇦🇹Innsbruck, Austria