Serum CXCL10 and CRP Levels in Patients with Acne Vulgaris in Correlation with Disease Severity

Not yet recruiting

• Conditions: Acne Vulgaris

• Registration Number: NCT06869109
• Lead Sponsor: Assiut University

Brief Summary

the correlations between CXCL10 levels, CRP, and acne severity scores (e.g., Global Acne Grading System) suggest that CXCL10 could serve as a biomarker of inflammation and acne severity. Understanding the relationship between CXCL10, CRP, and acne severity may offer insights into novel therapeutic strategies targeting inflammatory pathways in acne.

Detailed Description

Cross-sectional Observational Study. using 4 groups a 3 of different acne severity and controle one . the serum cxcl10 and crp will measured in each patient to correlate with disease severity

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-04
• Study First Submitted QC: 2025-03-07
• Last Update Submitted: 2025-03-07
• Study Start: 2025-03-10
• Study First Posted: 2025-03-11
• Last Update Posted: 2025-03-11
• Primary Completion: 2026-03-10
• Study Completion: 2026-04-10

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

1. Patients aged 12-40 years diagnosed with acne vulgaris.
2. Both genders included.
3. Patients with mild, moderate, or severe acne severity as determined by a validated scoring system (e.g., Global Acne Grading System).
4. Patients not on systemic acne treatment (e.g., isotretinoin or antibiotics) or anti-inflammatory drugs.

Exclusion Criteria

1. Patients with autoimmune diseases, systemic illnesses, acute infection or any other chronic inflammatory conditions that may affect CRP or CXCL10 levels.
2. Pregnant or lactating individuals.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of CXCL10 and CRP levels with acne severity (GAG score).	within one year after the result	compare the result of serum cxcl10 and crp with disease severity

Secondary Outcome Measures

Name	Time	Method
Identify thresholds of CXCL10 and CRP for predicting moderate/severe acne	within one year after the result	the least result to identify the group
Explore potential differences based on sex or age groups	within one year of the result	the effect of age and sex on the result

Trial Locations

Locations (1)

Assiut University; 🇪🇬 Assiut, Egypt