Metabolic Effects of Pneumoperitoneum During Laparoscopic Bariatric Surgery: Association Between Perioperative Serum Bicarbonate Change and Early Discharge Readiness
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Perioperative Serum Bicarbonate Change (ΔHCO₃-)
研究概览
简要总结
Pneumoperitoneum during laparoscopic bariatric surgery induces carbon dioxide absorption and may lead to perioperative alterations in acid-base balance. Serum bicarbonate (HCO₃-) plays a central role in metabolic compensation; however, the clinical relevance of perioperative bicarbonate changes remains insufficiently defined.
This prospective observational study aims to evaluate the association between pneumoperitoneum duration and perioperative serum bicarbonate change (ΔHCO₃-), and to investigate whether ΔHCO₃- is associated with early discharge readiness at 48 hours (DR-48) following laparoscopic bariatric surgery. Patients undergoing laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass will be enrolled consecutively. No alteration of routine clinical care will occur.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged ≥18 years
- •ASA physical status I-III
- •Scheduled for elective laparoscopic bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass)
- •Provided written informed consent
排除标准
- •Age <18 years
- •ASA physical status IV or higher
- •Chronic obstructive pulmonary disease (COPD), asthma, or other severe chronic respiratory disease
- •Known chronic metabolic acidosis or renal failure
- •Major intraoperative complications (e.g., severe bleeding, conversion to open surgery)
- •Postoperative reoperation, intensive care requirement, or complications preventing standard recovery evaluation
结局指标
主要结局
Perioperative Serum Bicarbonate Change (ΔHCO₃-)
时间窗: From baseline (after induction, before pneumoperitoneum) to 24 hours postoperatively
Change in serum bicarbonate (HCO₃-) between the preoperative value (after induction, before pneumoperitoneum) and the postoperative 24-hour value, calculated as: ΔHCO₃- = HCO₃-(24 h postoperative) - HCO₃-(preoperative). The association between pneumoperitoneum duration (minutes) and ΔHCO₃- will be evaluated.
次要结局
未报告次要终点
研究者
İlke Dolgun
Assoc. prof
Istinye University