A Laboratory Model for Heroin Abuse Medications - 8

Phase 2

Completed

• Conditions: Opioid-Related Disorders; Substance-Related Disorders; Heroin Dependence
• Interventions: Drug: opiates

• Registration Number: NCT00000273
• Lead Sponsor: New York State Psychiatric Institute

Brief Summary

The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."

Detailed Description

Abuse of prescription opioid medications has increased dramatically in the U.S. during the past decade, as indicated by a variety of epidemiological sources. However, few studies have systematically examined the relative reinforcing effects of commonly abused opioid medications. The current inpatient study was designed to compare the effects of intravenously delivered fentanyl , oxycodone, morphine, buprenorphine and heroin in morphine-maintained heroin abusers. All of the participants received all of the drugs tested; drugs and doses were administered in non-systematic order.

Study Timeline

• Study Start: 1995-08
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Primary Completion: 2005-11
• Study Completion: 2005-11
• Status Verified: 2017-06
• Last Update Submitted: 2017-07-03
• Last Update Posted: 2017-07-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Opiates	opiates	Opiate-dependent individuals who were currently not seeking treatment for their drug use, completed the 6-week protocol.

Primary Outcome Measures

Name	Time	Method
Amount drug self-administered	90 minutes	All of the participants received all of the drugs tested; drugs and doses were administered in non-systematic order. Participants were instructed to choose between the dose that they had received during the sample session or another reward..

Secondary Outcome Measures

Name	Time	Method
Subjective responses	90 min	Four questionnaires were used to assess subjective effects

Trial Locations

Locations (2)

New York State Psychiatric Institute; 🇺🇸 New York, New York, United States

Columbia University; 🇺🇸 New York, New York, United States