Ultrasonographic assessment of diaphragm to predict invasive ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- The value of Diaphragmatic impairment to predict need for invasive mechanical ventilation after NIV failure
研究概览
简要总结
COPD is the third leading cause of death worldwide. In case of respiratory failure, ventilatory support is necessary either in the form of NIV or IMV through endotracheal tube. Early use of NIV in patients with acute COPD is beneficial. The decision to institute IMV should be based on clinical judgement that integrates many clinical variables.
Ultrasonography is a non-invasive tool for quantification of diaphragmatic contractility through Diaphragmatic thickness or Diaphragmatic thickness fraction or diaphragmatic impairment. This makes USG assessment a reasonable tool during management plan.
This is a prospective observational study, which is going to happen over a period of 1 year.
The study sample was calculated using statistical package for the social sciences (version 20).
This study helps in assessing the ability of USG in predicting the requirement of IMV after NIV and also the impact of diaphragmatic impairment during ICU stay, MV days, and 28-day mortality.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 30.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of either sex admitted to the intensive care unit with acute exacerbation of chronic obstructive pulmonary disease.
排除标准
- •1.Contraindications of Non-invasive ventilation (unconscious uncooperative patients,shock,severe hemodynamic instability) 2.Neuromuscular disease 3.Chest wall deformities 4.Diaphragmatic palsy.
结局指标
主要结局
The value of Diaphragmatic impairment to predict need for invasive mechanical ventilation after NIV failure
时间窗: On admission, before starting NIV and after starting NIV
次要结局
- Impact of Diaphragmatic impairment.(1. During Mechanical ventilatory days)