Is Antibiotic Therapy Mandatory for Treatment of Uncomplicated Acute Colonic Diverticulitis: a Randomized Clinical Trial

Uppsala University1 site in 1 country600 target enrollmentNovember 2002

ConditionsColonic Diverticulitis

InterventionsAntibiotic

DrugsAntibiotic

Overview

Phase: Not Applicable
Intervention: Antibiotic
Conditions: Colonic Diverticulitis
Sponsor: Uppsala University
Enrollment: 600
Locations: 1
Primary Endpoint: discharge without complications +/- antibiotic therapy
Status: Completed
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.

The hypothesis is that Patients with acute uncomplicated colonic diverticulitis will recover the condition without antibiotic therapy and the lack of antibiotic therapy will not lead to complications.

The patients will be randomized to conservative treatment with and without antibiotic therapy.

Registry

clinicaltrials.gov

Start Date

November 2002

End Date

December 2010

Last Updated

14 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Uppsala University

Responsible Party

Principal Investigator

achabok

Uppsala University

Eligibility Criteria

Inclusion Criteria

•adults with CT sign of acute colonic uncomplicated diverticulitis
•elevated CRP and LPK
•Temp.38c or more

Exclusion Criteria

•patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air
•pregnancy
•immunological incompetence and immunosuppressive therapy