Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis

Not Applicable

Completed

• Conditions: Colonic Diverticulitis
• Interventions: Drug: Antibiotic

• Registration Number: NCT01008488
• Lead Sponsor: Uppsala University

Brief Summary

The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.

The hypothesis is that Patients with acute uncomplicated colonic diverticulitis will recover the condition without antibiotic therapy and the lack of antibiotic therapy will not lead to complications.

The patients will be randomized to conservative treatment with and without antibiotic therapy.

Detailed Description

Not available

Study Timeline

• Study Start: 2002-11
• Study First Submitted: 2009-11-04
• Study First Submitted QC: 2009-11-04
• Study First Posted: 2009-11-05
• Primary Completion: 2010-05
• Study Completion: 2010-12
• Status Verified: 2011-12
• Last Update Submitted: 2011-12-22
• Last Update Posted: 2011-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

• adults with CT sign of acute colonic uncomplicated diverticulitis
• elevated CRP and LPK
• Temp.38c or more

Exclusion Criteria

• patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air
• pregnancy
• immunological incompetence and immunosuppressive therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Antibiotic	Antibiotic	-

Primary Outcome Measures

Name	Time	Method
discharge without complications +/- antibiotic therapy	Within 30 days after discharge

Secondary Outcome Measures

Name	Time	Method
to evaluate length of hospital stay, cost and late complications	one year after admission

Trial Locations

Locations (1)

The Central Hospital; 🇸🇪 Västerås, Västmanland, Sweden