NCT01008488已完成不适用
Is Antibiotic Therapy Mandatory for Treatment of Uncomplicated Acute Colonic Diverticulitis: a Randomized Clinical Trial
Uppsala University1 个研究点 分布在 1 个国家目标入组 600 人开始时间: 2002年11月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- discharge without complications +/- antibiotic therapy
研究概览
简要总结
The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.
The hypothesis is that Patients with acute uncomplicated colonic diverticulitis will recover the condition without antibiotic therapy and the lack of antibiotic therapy will not lead to complications.
The patients will be randomized to conservative treatment with and without antibiotic therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adults with CT sign of acute colonic uncomplicated diverticulitis
- •elevated CRP and LPK
- •Temp.38c or more
排除标准
- •patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air
- •pregnancy
- •immunological incompetence and immunosuppressive therapy
研究组 & 干预措施
Antibiotic
Active Comparator
干预措施: Antibiotic (Drug)
结局指标
主要结局
discharge without complications +/- antibiotic therapy
时间窗: Within 30 days after discharge
次要结局
- to evaluate length of hospital stay, cost and late complications(one year after admission)
研究者
achabok
MD
Uppsala University
研究点 (1)
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