Dose-dependent Impact of Daytime Lighting on Evening Responses to Light

Not Applicable

• Conditions: Sleep
• Interventions: Behavioral: Light

• Registration Number: NCT04882280
• Lead Sponsor: Palo Alto Veterans Institute for Research

Brief Summary

The purpose of this study is to systematically examine the impact of different intensities of daytime light and the subsequent impact that such exposure has on non-image forming responses to light in the evening.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-05-07
• Study First Submitted QC: 2021-05-07
• Study First Posted: 2021-05-11
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-02
• Last Update Posted: 2022-03-17
• Study Start: 2022-07
• Primary Completion: 2024-06
• Study Completion: 2024-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

1. Aged 18-65
2. Good health
3. Male or female
4. Normal color vision

Exclusion Criteria

1. Sleep disorders
2. Extreme chronotypes
3. Routine smoker
4. Significant hearing loss
5. Depressed
6. Alcohol use disorder
7. Use of illegal drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low room	Light	Low intensity (80 lux) room light
Normal room	Light	Normal intensity (150 lux) room light
Bright	Light	Very high intensity (1000 lux) room light
Bright room	Light	High intensity (500 lux) room light

Primary Outcome Measures

Name	Time	Method
Suppression of melatonin production	4 hours	Difference in salivary melatonin concentrations between active arm and 3 lux control condition
Phase shift in the timing of melatonin onset	2 days	Change in the onset of melatonin secretion after experimental stimulus

Trial Locations

Locations (1)

VA Palo Alto Health Care System; 🇺🇸 Palo Alto, California, United States