Dose-dependent Impact of Daytime Lighting on Evening Responses to Light
试验速览
- 阶段
- 不适用
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Suppression of melatonin production
研究概览
简要总结
The purpose of this study is to systematically examine the impact of different intensities of daytime light and the subsequent impact that such exposure has on non-image forming responses to light in the evening.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Good health
- •Male or female
- •Normal color vision
排除标准
- •Sleep disorders
- •Extreme chronotypes
- •Routine smoker
- •Significant hearing loss
- •Alcohol use disorder
- •Use of illegal drugs
研究组 & 干预措施
Low room
Low intensity (80 lux) room light
干预措施: Light (Behavioral)
Normal room
Normal intensity (150 lux) room light
干预措施: Light (Behavioral)
Bright room
High intensity (500 lux) room light
干预措施: Light (Behavioral)
Bright
Very high intensity (1000 lux) room light
干预措施: Light (Behavioral)
结局指标
主要结局
Suppression of melatonin production
时间窗: 4 hours
Difference in salivary melatonin concentrations between active arm and 3 lux control condition
Phase shift in the timing of melatonin onset
时间窗: 2 days
Change in the onset of melatonin secretion after experimental stimulus
次要结局
未报告次要终点
研究者
Jamie M. Zeitzer, Ph.D.
Associate Professor
VA Palo Alto Health Care System