Investigating the anti-inflammatory effect of colchicine in patients undergoing coronary artery bypass graft

Phase 3

Recruiting

• Conditions: Coronary Artery Disease.; Atherosclerotic heart disease of native coronary artery; I25.1

• Registration Number: IRCT20220907055908N1
• Lead Sponsor: Semnan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 November 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

patients over 30 years old and under 80 years old
patients needing CABG surgery
Informed consent

Exclusion Criteria

patients should have contraindications to colchicine or atorvastatin
patients with a history of severe liver diseases
patients who have creatinine clearance less than 50.
patients with a history of atrial fibrillation or atrial flutter or 2nd and 3rd-degree heart block
patients with autoimmune diseases or a history of taking immunosuppressive drugs in the last 1 month
patients with heart failure Ejection Fraction < 35%
patients with a history of muscle conflicts
patients of taking fibrate drugs
patients with leukopenia or active infection
patients with acute coronary syndrome

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interleukin 6. Timepoint: Before and after the intervention. Method of measurement: ELISA method.;CRP. Timepoint: Before and after the intervention. Method of measurement: Spectrophotometry.;LDH. Timepoint: Before and after the intervention. Method of measurement: Spectrophotometry.;ESR. Timepoint: Before and after the intervention. Method of measurement: Spectrophotometry.

Secondary Outcome Measures

Name	Time	Method
AF rhythm occurrence. Timepoint: Before and after the intervention. Method of measurement: Electrocardiogram(¬ECG).;Gastrointestinal side effects (nausea, heartache, diarrhea and vomiting). Timepoint: after the intervention. Method of measurement: Examination.;Death. Timepoint: after the intervention. Method of measurement: Examination.