Effect of General Anesthesia Method on Cardiac Risk Patients on Ischemia Modified Markers

Not Applicable

Not yet recruiting

• Conditions: Anesthesia
• Interventions: Procedure: TIVA; Procedure: GENERAL ANESTHESIA

• Registration Number: NCT05662163
• Lead Sponsor: Ataturk University

Brief Summary

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers

Detailed Description

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers like; serum levels of the Creatine Kinase, Creatine Kinase Myocardial Band, high sensitive troponin, heart-type fatty acid-binding protein, ischemia-modified albumin and albumin. And evaluate the effect of anesthesia method on haemodynamic.

Study Timeline

• Study First Submitted: 2022-09-06
• Status Verified: 2022-12
• Study First Submitted QC: 2022-12-14
• Last Update Submitted: 2022-12-14
• Study First Posted: 2022-12-22
• Last Update Posted: 2022-12-22
• Study Start: 2022-12-30
• Primary Completion: 2023-06-30
• Study Completion: 2023-12-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Being 18 years or older
• Getting a score of 2 and above according to the Lee cardiac index
• Having a non-cardiac surgical procedure that will take at least three hours
• ASA II or III

Exclusion Criteria

• Under 18 years old
• Those who refused to participate in the study
• Patients with chronic renal failure
• Patients with creatinine value ≥ 1.5 mg/dl
• Surgery that takes less than 3 hours
• Patients with liver failure
• Refusing to participate in the study
• Being allergic to the drugs used

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
GROUP TIVA	TIVA	Anesthesia will be maintained with propofol (6-10 mg/kg/hour) and remifentanil (0.1-0.3 μg/kg/min). Blood will be taken from the patients at 0, 1 and 4 hours, centrifuged and stored at -80 degrees. From these examples, CK, CKMB, HIGH SENSITIVE TROPONIN, HFABP, IMA AND ALBUMIN will be studied.
GROUP INHALATION ANESTHESIA	GENERAL ANESTHESIA	Anesthesia will be maintained with sevoflurane (2 ml/min) 50% oxygen and remifentanil (0.1-0.3 μg/kg/min). Blood will be taken from the patients at 0, 1 and 4 hours, centrifuged and stored at -80 degrees. From these examples, CK, CKMB, HIGH SENSITIVE TROPONIN, HFABP, IMA AND ALBUMIN will be studied.

Primary Outcome Measures

Name	Time	Method
comparing serum levels of heart fatty acid binding protein	intraoperative period	serum levels of heart fatty acid binding protein (in terms of mcg/L)
comparing serum levels of ischemia modified albumin	intraoperative period	serum levels of ischemia modified albumin (in terms of IU/ML)

Secondary Outcome Measures

Name	Time	Method
The effect of anesthesia method used in cardiac risk patients in terms of ephedrine consumption	intraoperative period	used ephedrine amount (mg)