NCT00259233已完成不适用
The Effects of Peripheral Administration of Saline, PYY1-36 and PYY3-36 on ad Libitum Energy Intake and Appetite.
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 主要终点
- appetite
研究概览
简要总结
12 obese subjects will receive peripheral administration of placebo and 4 escalating doses of PYY1-36 and another 12 obese subjects will receive peripheral administration of placebo and 4 escalating doses PYY3-36 on 5 different test days within one week. The patients will be tested in a single blinded dose escalating protocol. Measurements of appetite, ad libitum energy intake, blood pressure and blood sampling will be performed during the test day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Normal weight (BMI: 18-23 kg/m2) or 12 overweight/obese (BMI: 27-40 kg/m2)
- •Body weight fluctuations < 5 kg over the past 2 months.
- •Blood pressure normal to mildly hypertensive(<159/99 mm Hg)
- •Non-elite athletes and not planning to change physical activity during the study.
排除标准
- •Any physiological or psychological illnesses that could influence the study results.
- •Regular use of medicine.
- •Smoking defined as <1 cigarette per day.
- •Substance abuse or dependence.
- •Blood donation within the past 3 months before entering the study.
- •Drinking >21 alcoholic units/week.
- •Food allergies.
- •Special diets (e.g. vegetarian) or dislikes to any of the foods served during the study.
结局指标
主要结局
appetite
energy intake
次要结局
- Plasma PYY profile
- Blood pressure
研究者
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