Effect of Preoperative Oral Carbohydrate Shortening the Fasting Period on Hypotension After Anesthesia Induction in Elderly Patients With Joint Replacement
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 210
- 主要终点
- Incidence of hypotension
研究概览
简要总结
The goal of this Randomized controlled trial is to investigate the effect of shortening the duration of preoperative oral carbohydrate drinks on blood pressure after anesthesia induction in elderly patients undergoing joint replacement surgery. The main question it aims to answer is Whether preoperative oral carbohydrate drinks can reduce the incidence of hypotension after anesthesia-induced hypotension in elderly patients undergoing joint replacement surgery.According to the numerical table method, the patients in the experimental group will drink carbohydrate drinks the night before the operation and 3 hours before the operation, and the control group patients will routinely fast
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing elective unilateral joint replacement (total hip or knee)
排除标准
- •Diagnosed patients at high risk of reflux aspiration (diabetes mellitus, obesity (BMI>30), gastrointestinal obstruction, elevated intracranial pressure, and esophageal disease)
- •Eating disorders
- •History of gastrointestinal or epigastric surgery
- •Recent use of drugs that affect gastrointestinal motility
- •Heart disease (severe arrhythmias, severe heart valve disease, heart failure, unstable angina on the day of surgery)
- •Severe poorly controlled hypertension (MAP≥135 mmHg) or hypotension (MAP≤55 mmHg) before induction
- •Difficult airway
- •Severe hepatic and renal insufficiency
结局指标
主要结局
Incidence of hypotension
时间窗: 20 minutes after induction of anesthesia
No surgical manipulation is performed within 20 minutes
次要结局
- Duration of fasting and drinking(1 day before the operation)
- Incidence of hypotension(during the whole operation)
- Antral cross-sectional area(30 minutes before anesthesia induction)
- The dosage of vasoactive drugs(20 minutes after induction of anesthesia)
- Thirst and hunger VAS score(3 hours before and 1 day after the operation)
- Fasting blood glucose and insulin resistance index(3 hours before the operation)
- Incidence of nausea and vomiting(1 day after the operation)