Skip to main content
MedPath Trial logoMedPath TrialMedPath Trial Home
Clinical Trials/JPRN-jRCT1052180225
JPRN-jRCT1052180225CompletedPhase 4

Efficacy and Safety of long-term high-flow nasal cannula oxygen therapy in stable COPD patients with home oxygen therapy (HOT): a multicenter, prospective, randomized controlled study - FLOCOP study

Tomii Keisuke0 sites104 target enrollmentStarted: March 29, 2019Last updated:
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit

Trial Snapshot

Phase
Phase 4
Status
Completed
Sponsor
Enrollment
104
Study OverviewEligibility CriteriaInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Compared to the HOT alone, HOT plus HFNC therapy improved the frequency of moderate or severe COPD exacerbation and prolonged the time to the first moderate or severe COPD exacerbation. In addition, PaCO2, SpO2, SGRQ-C, SRI, FVC, %FVC, FEV1, and %FEV1 in HFNC group showed trend of improvement over the observational period, but significant differences were observed only in some visit in SpO2, FVC, %FVC, FEV1 and %FEV1.

Study Design

Study Type
Interventional

Eligibility Criteria

Ages
>= 40age old to ot applicable (—)
Sex
All

Inclusion Criteria

  • •1. Patients who are diagnosed with the global initiative on obstructive lung disease (GOLD) stage 2-4 COPD.
  • •2. Patients who have received nocturnal HOT 16 hours or more per day for 1 month or more at the time of the informed consent.
  • •3. Patients with PaCO2 >= 45 Torr and pH >= 7.35 at screening.
  • •4. Patients with COPD exacerbation (Moderate or Severe; judged by the investigators) within the past 1 year prior to the informed consent.
  • •5. Patients who are more than 40 years old at the time of the informed consent.
  • •6. Patients who agree to participate in the study with the written informed consent.

Exclusion Criteria

  • •1. Patients with severe kidney, liver or cardiovascular disease.
  • •2. Patients with active malignant tumor.
  • •3. Patients with acute disease.
  • •4. Patients who are diagnosed with asthma. (Excluding COPD patients with history of asthma).
  • •5. Patients who have any history of the diagnosis with obstructive sleep apnea syndrome (OSAS) or are highly-suspected cases in the clinical. (Excluding patients who are denied the diagnosis of OSAS by the result of overnight polysomnography.)
  • •6. Patients with diseases that affecting the efficacy endpoints (for example: active pulmonary infection, clinically significant pulmonary fibrosis and bronchiectasis, a1-antitrypsin deficiency etc.,) and are regarded as inadequate for the study by the investigators.
  • •7. Patients who have experienced a COPD exacerbation (any Severity: judged by the investigators) within the past 4 weeks prior to the informed consent.
  • •8. Patients who are receiving nocturnal noninvasive positive pressure ventilation (NPPV), or who had been received it within 4 weeks prior to the informed consent.
  • •9. Patients who have used HFNC at home within the past 1 year prior to the informed consent, or are using any HFNC. (Excluding patients who used HFNC during hospitalization due to acute respiratory failure within 1 year prior to the informed consent.)
  • •10. Patients with history of tracheotomy, severe pharyngeal surgery or severe nasal cavity surgery within the past 6 months prior to the informed consent.
  • •11. Patients who are pregnant.
  • •12. Patients with cognitive impairment or mental disorder who are regarded as inadequate to evaluate for the study by the investigators.
  • •13. Patients who are regarded as being unable to operate the myAIRVO2 adequately at home by the investigators.
  • •14. Patients who have participated in the other study at the time of the informed consent, or will participate in the other study.
  • •15. Any other cases who are regarded as inadequate for the study enrollment by the investigators.

Investigators

Sponsor
Tomii Keisuke

Similar Trials

Completed
Not Applicable
Efficacy and Safety of long-term high-flow nasal cannula oxygen therapy in stable COPD patients with home oxygen therapy (HOT): a multicenter, prospective, randomized controlled study
JPRN-UMIN000028581Kobe City Medical Center General Hospital Department of Respiratory Medicine120
Completed
Not Applicable
Nasal High Flow (NHF) in COPD - Effects on Ventilation in WakefulnessCOPD
NCT05053074Institut für Pneumologie Hagen Ambrock eV10
Unknown
Not Applicable
High Flow Nasal Cannula and HypercapniaCOPD
NCT03759457IRCCS Azienda Ospedaliero-Universitaria di Bologna50
Completed
Not Applicable
Study of Long-term HFNC for COPD Patients with HOTChronic Obstructive Pulmonary Disease (COPD)
NCT03282019Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan120
Completed
Not Applicable
Efficacy and Physiology of Nasal High Flow TherapyPulmonary Disease, Chronic Obstructive
NCT02083120Institut für Pneumologie Hagen Ambrock eV46
Study of long-term HFNC for COPD patients... | Clinical Trial