Inflammatory Response After One-lung Ventilation According to Ventilation Methods

Not Applicable

Completed

• Conditions: Lung Cancer
• Interventions: Other: Ventilation method

• Registration Number: NCT04007354
• Lead Sponsor: Seoul St. Mary's Hospital

Brief Summary

Unlike conventional thoracic surgery performed under general anesthesia with tracheal intubation, non-intubated thoracic surgery with sedation and regional anesthesia has been performed recently. Non-intubated thoracic surgery is expected to reduce the postoperative inflammatory changes by maintaining more physiologic status during the operation compared to intubated thoracic surgery. The aim of this study was to compare perioperative immunological changes between intubated and non-intubated thoracic surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-25
• Primary Completion: 2019-04-19
• Study Completion: 2019-05-20
• Status Verified: 2019-06
• Study First Submitted: 2019-07-01
• Study First Submitted QC: 2019-07-01
• Last Update Submitted: 2019-07-02
• Study First Posted: 2019-07-05
• Last Update Posted: 2019-07-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• elective video-assisted thoracoscopic surgery (VATS) lobectomy
• 20 < age < 75
• American Society of Anesthesiologists (ASA) classification I~II

Exclusion Criteria

• preoperative inflammation (CRP>10ng/㎖, WBC>10,000/mm3, body temperature >38℃)
• steroid administration within 1 month
• hematologic / autoimmune disease
• congestive heart failure (NYHA class III~IV) or significant arrhythmia
• severe obstructive / restrictive pulmonary disease
• previous history of thoracic surgery
• BMI >28kg/m2
• expected difficult airway

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Non-intubated	Ventilation method	The patients were oxygenated via facial mask with O2 5\~10 L/min during the whole procedure. The end-tidal carbon dioxide (EtCO2) was measured by insertion of a detector inside one of the nostrils. Respiration rate was maintained between 12 and 20 breaths/min with adjustment of anesthetics.

Primary Outcome Measures

Name	Time	Method
Interleukin (IL)-6	24 hours after surgery	Blood samples collected from the antecubital vein

Trial Locations

Locations (1)

Seoul St.Mary's Hospital; 🇰🇷 Seoul, Korea, Republic of