Influence of Lidocaine on a Closed-Loop Anesthesia System

Hopital Foch1 site in 1 country82 target enrollmentJanuary 2011

Overview

Phase: Phase 3
Intervention: Lidocaine
Conditions: Anesthesia
Sponsor: Hopital Foch
Enrollment: 82
Locations: 1
Primary Endpoint: administered dose of propofol during maintenance of anesthesia
Status: Completed
Last Updated: 9 years ago

The objective is to evaluate the sparing effect of Lidocaine on doses of propofol and remifentanil.

Registry

clinicaltrials.gov

Start Date

January 2011

End Date

January 2015

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Sponsor

Responsible Party

Sponsor

•patients ASA 1, 2 or 3 scheduled for a general anesthesia surgical procedure (abdominal surgery, urology, ENT major procedure) lasting between 1 and 3 hours

Patients will receive a closed-loop administration of propofol and remifentanil according to bispectral level and Lidocaine

Intervention: Lidocaine

patients will receive a closed-loop administration of propofol and remifentanil according to bispectral level and a placebo

Intervention: Placebo

administered dose of propofol during maintenance of anesthesia

Time Frame: day 1

delay (measured as minutes) between the end of propofol and remifentanil administration and the recovery from anesthesia(day 1)
postoperative morphine requirement(day 1)
incidence of postoperative nausea and vomiting(day 1)
% of patients with an explicit memorisation of the intraoperative period(second postoperative day)
administered dose of propofol during induction of anesthesia(day 1)
administered doses of remifentanil during induction and maintenance of anesthesia(day 1)
hemodynamic abnormalities requiring treatment(day 1)
% of time with a BIS index between 40 and 60(day 1)