Membrane Shedding During Septic Shock

Completed

• Conditions: Septic Shock

• Registration Number: NCT01604551
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This is a prospective observational study of circulating MPs and blood coagulation in 100 septic shock patients admitted in 3 tertiary hospitals medical ICU at baseline (D1), D2, D3, D4 and D7.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-05
• Study Completion: 2011-12
• Status Verified: 2012-05
• Study First Submitted: 2012-05-21
• Study First Submitted QC: 2012-05-21
• Study First Posted: 2012-05-23
• Last Update Submitted: 2012-05-31
• Last Update Posted: 2012-06-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Septic shock
• Informed consent

Exclusion Criteria

• Class IV heart failure
• Child-Plugh grade C cirrhosis
• Cancer under active treatment
• BMI>35 kg/m²
• Moribund patient
• DNR decision

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (3)

Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires; 🇫🇷 Strasbourg, France

Service Réanimation Médicale et Médecine Hyperbare, CHU; 🇫🇷 Angers, France

Centre Hospitalier; 🇫🇷 Mulhouse, France