Direct Comparison of 2D Cardiac PET With 3D Cardiac PET
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT01993303
- Lead Sponsor
- Cardiovascular Imaging Technologies
- Brief Summary
Lowering the per-infusion dose of Rb-82 offers advantages of lessening radiation exposure and extending useable generator life. Prior studies have not shown equivalence of 3D vs 2D Rb-82 PET. The investigators therefore compare 3D PET after a lower Rb-82 dose (\~20 mCi) processed using a Monte-Carlo driven scatter correction algorithm against conventional higher dosage (\~50 mCi) 2D Rb-82 PET MPI.
- Detailed Description
This study re-examines 2D an 3D myocardial perfusion PET data from 19 subjects, mean age 65 years, mean BMI 30 kg/m2, 79% male. Rest and stress scans were acquired on a Siemens Accel™ PET scanner in 2D (septa extended) and 3D (septa retracted) modes. Rb-82 doses were rest 53+/-5 mCi and stress 53+/-6 mCi. Imaging times were 2D emission scan for 3 mins (90 sec delay post Rb-82 infusion), followed by a 3 minute, 3D gated emission scan (180 sec delay). Decay and shorter acquisition times led to a 62% reduction in the effective dosage 2D vs 3D datasets. 3D images were first pre-processed using a Monte-Carlo scatter and prompt gamma correction algorithm (Imagen3D™) then reconstructed using ImagenProTM (CVIT, Kansas City, MO). Reconstructed images were evaluated using relative, 17 segment raw scores (Cedars QPET). Studies were read by consensus of 2-blinded readers for: image quality (1-4, poor-excellent), interpretive certainty (1-3, low-high) and rest perfusion using a 17 segment model (0=normal; 1-3 = mild, moderate, or severe perfusion defects). Stress segmental scores were not evaluated due to differences in imaging start time post dipyridamole infusion.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 19
- >18 Years of Age
- Have ability to provide informed consent
- Have a technically adequate rest/stress Rb-82 perfsion PET study within the past 60 days
- Pregnant or nursing feamle
- Weight > 275 lbs
- Have contraindications to adenosine stress testing
- Unstable cardiac rhythm (atrial fibrillation, frequent PVCs
- PTCA or CABG within the last 60 days
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantitative Accuracy 1 day To establish the quantitative accuracy of reconstructed volumes using Imagen3DTM when compared to other methods.
Visual Assessment 1 day To establish that visual assessments of image quality and reader confidence using 3D data are equivalent to the other methods.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Saint Lukes Hospital
🇺🇸Kansas City, Missouri, United States