NCT03032627进行中（未招募）不适用
Identifying Targets of Maladaptive Metabolic Responses in Heart Failure
AdventHealth Translational Research Institute2 个研究点 分布在 1 个国家目标入组 55 人开始时间: 2017年3月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 55
- 试验地点
- 2
- 主要终点
- Analyses of collected tissues
研究概览
简要总结
The purpose of the research is to help researchers understand changes in metabolism in patients that develop heart failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects are capable of giving informed consent.
- •Diagnosis of chronic heart failure
- •Any patients scheduled for at least one of the following procedures:
- •LVAD implantation or as recipient for cardiac transplantation.
- •LVAD placement both as bridge to transplant and as destination therapy.
- •LVAD explantation
- •Valve replacement or repair
- •Catheterization and myocardial biopsy for idiopathic cardiomyopathy
- •Coronary artery bypass graft (CABG)
排除标准
- •Life expectancy less than 2 weeks
- •Diagnosed with following co-morbidities: cancer, chronic kidney disease (GFR≤30 or serum creatinine >2.1), active infection or treatment with antibiotics or persistent infectious disease (hepatitis, HIV, etc), cirrhosis, active substance abuse and/or alcohol dependence (≥ 14 alcoholic beverages per week).
- •Control Myocardial Tissue from Donor Hearts Inclusion Criteria
- •Samples collected from non-failing hearts deemed unsuitable for transplantation by TransLife because of either acute recipient issues or post-harvest evidence of pathology or positive but benign serology.
- •Normal cardiac function from medical records
- •Exclusion Criteria:
- •Pathological remodeling and extensive infarction with limited non-pathological regions of myocardium.
- •Abnormal or impaired cardiac function from medical records, which are self determinants for rejection as a donor organ.
结局指标
主要结局
Analyses of collected tissues
时间窗: Restricted to the time around surgical procedure
Tissue samples collected during surgery will be analyzed by way of immunoblot and qrtPCR of mRNA for metabolic enzymes on neutralized acid extracts.
次要结局
未报告次要终点
研究者
研究点 (2)
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