Detection of Autologous DEHP (DiEthylHexyl Phthalate)-Free Blood Transfusion Using a Combination of Multiple Biomarkers in Different Matrices.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Measurement of blood parameters profile, iron metabolism and genomic compounds
研究概览
简要总结
The aim of the proposed project is to perform a clinical study in which volunteers will receive autologous blood transfusions in DEHP-free blood bags.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Have to fill the swiss blood donation formulary
排除标准
- •Cardiovascular disease
- •Neurologic disease
- •Not performed a blood donation for 5 weeks ago the start of the study.
- •Immunological disease
研究组 & 干预措施
Blood bags without DEHP
Intervention : Autologous blood transfusion
干预措施: Autologous blood transfusion (Biological)
Blood bags with DEHP
Intervention : Autologous blood transfusion
干预措施: Autologous blood transfusion (Biological)
结局指标
主要结局
Measurement of blood parameters profile, iron metabolism and genomic compounds
时间窗: 1 month
Blood profiling such as measurement of concentration of different blood cells and hemoglobin will be measured up to 15 days after blood-reinfusion. Concentration of free-iron, ferritin and hepcidin will be measured in plasma and serum up to 15 days after blood re-infusion. Concentration of circulating microRNAs will be measured in plasma also up to 15 days after blood re-infusion. All measures are compared.
次要结局
未报告次要终点
研究者
Nicolas Leuenberger
Dr, PhD
Centre Hospitalier Universitaire Vaudois