Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population
- Conditions
- MigraineCerebral InfarctionRight-to-left Shunt
- Registration Number
- NCT02425696
- Lead Sponsor
- Yingqi Xing
- Brief Summary
The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.
- Detailed Description
This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and c-TCD). For migraineurs with large RLS further examinations (c-TTE and brain MRI) are required. Up to 10 study sites nationwide will be needed to recruit the planned participant population during a 1-year period.
The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, MIDAS and HIT-6 questionnaire.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1100
- For group 1: Normal healthy individual without migraine.
- For group 2: Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.
- Subjects with stenotic intracranial or extracranial arteries or intracranial abnormalities diagnosed with TCD.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method contrast-enhanced transcranial Doppler 1 year
- Secondary Outcome Measures
Name Time Method brain MRI 1 year
Trial Locations
- Locations (1)
First Hospital of Jilin University
🇨🇳Changchun, Jilin, China