NCT01718418已完成早期 1 期
Prebiotics and Probiotics as Means to Modulate Colonic Events, With Specific Focus on Metabolism and Satiety
适应症
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Differences in concentration of risk markers in blood, measured post-prandial after a breakfast meal.
研究概览
简要总结
The purpose of the study is to evaluate food factors related to colonically derived regulation of glucose metabolism (and related parameters) and satiety using a semi-acute meal study in healthy subjects as experimental model.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal fasting blood glucose, BMI 19-25 kg/m2, for women: hormon based contraceptives
排除标准
- •gastrointestinal diseases or food allergies e.g. lactose-, gluten intolerance, metabolic disorders e.g. diabetes, tobacco/snuff users. Antibiotic or probiotic usage within two weeks, and during the study. Vegetarians
结局指标
主要结局
Differences in concentration of risk markers in blood, measured post-prandial after a breakfast meal.
时间窗: Post-prandially after breakfast, 0-210 min
Variables (blood glucose, insulin, incretin, inflammatory markers, markers of colonic fermentation) are measured after two-weeks ingestion of test products. The experimental day is terminated after a lunch meal.
次要结局
- voluntary energy intake(Post-prandially after breakfast, 0-210 min)
- Differences in gut microbiota(Faecal samples are collected after 14 days intake of test- and reference product)
- Subjective satiety(post-prandially after breakfast, 0-210 min)
研究者
Elin Johansson
MSc, post-graduate student
Lund University
研究点 (2)
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