Comparison of imaging pattern and diagnostic value of F-18 FLT and F-18 FDG PET in patients with rectal cancer before and after neoadjuvant radiochemotherapy
- Conditions
- anorectal cancer
- Registration Number
- EUCTR2006-003828-11-AT
- Lead Sponsor
- Prim. Univ.Prof. Dr. Christian Pirich Department of Nuclear Medicine and Endocrinology, PMU Salzburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Included in this study will be between 18 and 80 years old male and female patients with proven rectal tumour (by biopsy and histology).
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Excluded from this study are patients that are not able to lie motionless without pain for one hour, pregnant women and breast-feading women.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: The comparison of F-18 FLT and F-18 FDG tumour uptake before and after neoadjuvant radiochemotherapy (related to clinical, radiological and PET-CT criteria of response) and the evaluation of the tumour response to therapy. ;Secondary Objective: The relation and comparison of the F-18 FLT and F-18 FDG uptake pattern of rectal tumours to the molecular tumour pattern and the determination of differences of F-18 FLT and F-18 FDG uptake (degree of tumour proliferation, glycolysis and histological signs of concomitant inflammation).;Primary end point(s): ?
- Secondary Outcome Measures
Name Time Method