The Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans: A Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Pulse wave velocity (carotid-to-femoral)
研究概览
简要总结
The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Self-identify as African American/Black
- •Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet
- •Age 18-40
排除标准
- •History of smoking within 2 years or being a current smoker
- •Taking vasoactive medications
- •Having overt cardiovascular, metabolic, or neurological disease
- •Pregnant individuals
结局指标
主要结局
Pulse wave velocity (carotid-to-femoral)
时间窗: Day 1
Central blood pressure (systolic, diastolic, mean)
时间窗: Day 1
Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline)
时间窗: Day 1
Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG)
时间窗: Day 1
Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline)
时间窗: Day 1
C-reactive protein
时间窗: Day 1
Augmentation index (AIx@HR75)
时间窗: Day 1
Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline)
时间窗: Day 2
Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline)
时间窗: Day 2
Peripheral blood pressure (systolic, diastolic, mean)
时间窗: Day 1
次要结局
未报告次要终点
研究者
Matthew Brothers
Associate Professor
The University of Texas at Arlington